The aggregation of proteins into structures known as amyloids is observed in many
neurodegenerative diseases, including Alzheimer's disease. Amyloids are composed of …

Antisense oligonucleotides represent a novel therapeutic platform for the discovery of
medicines that have the potential to treat most neurodegenerative diseases. Antisense …

Formation of amyloid fibrils underlies a wide range of human disorders, including
Alzheimer's and prion diseases. The amyloid fibrils can be readily detected thanks to …

Though emerging evidence indicates that the pathogenesis of Parkinson's disease is
strongly correlated to the accumulation, and transmission, of α-synuclein (α-syn) aggregates …

Phototherapy has emerged as a powerful approach for interrupting β‐amyloid (Aβ) self‐
assembly. However, deeper tissue penetration and safer photosensitizers are urgent to be …

Amyloids, fibrillar assembly of (poly) peptide chains, are associated with neurodegenerative
illnesses such as Alzheimer's and Parkinson's diseases, for which there are no cures. The …

Summary α-Synuclein (α-syn) aggregation is a key event in Parkinson's disease (PD).
Mutations in glycosphingolipid (GSL)-degrading glucocerebrosidase are risk factors for PD …

Parkinson's disease (PD) is one of the most debilitating brain diseases. Despite the
availability of symptomatic treatments, response towards the health of PD patients remains …

The impact of proteins and peptides on the treatment of various conditions including ocular
diseases over the past few decades has been advanced by substantial breakthroughs in …

Because of the extremely polarized morphology, the proper functioning of neurons largely
relies on the efficient cargo transport along the axon. Axonal transport defects have been …