Klotho is an identified longevity gene with beneficial pleiotropic effects on the kidney.
Evidence shows that a decline in serum Klotho level occurs in early chronic kidney disease …

Biological aging occurs as a result of the interaction between genetics, chronological age
and external factors. It is the basis for new concepts of vascular aging, whose progression is …

As doenças cardiovasculares são anualmente responsáveis por quase um terço do total de
mortes no mundo. Dentre elas, a hipertensão arterial sistêmica (HAS) está relacionada …

Background: Cardiovascular disease, such as coronary heart disease (CHD), are the main
cause of mortality and morbidity worldwide. CHD is not entirely predicted by classic risk …

Frailty and cardiovascular disease share some of the pathophysiologic features. Our
objective was to review and metaanalyse the available published evidence on the topic. We …

Methods: A cross-sectional study was conducted from 2012 to 2017, 603 participants were
included: 517 patients and 86 'healthy'individuals used to calculate the theoretical PWV …

BACKGROUND Coronary heart disease (CHD) is among the main causes of death in the
world. Individual study of cardiovascular risk is an important way to predict CHD risk. The …

Objective: Aortic stiffness may provide information to classical risk factors information
regarding cardiovascular risk. Aortic pulse wave velocity (PWV) can be measured by …

Introduction. Maternal age for the first pregnancy is increasing and so, the prevalence of
cardiovascular risk factors in pregnancy is also increasing. Heart disease is the main reason …

O envelhecimento biológico é reflexo da interação entre genética, idade cronológica e
fatores externos; é a base para novos conceitos em envelhecimento vascular, cuja …