Biomarkers are biological molecules found in body fluids or tissues, which can be
considered as indications of a normal or abnormal process, or of a condition or disease …

Highlights•B-cell precursor acute lymphoblastic leukemia (BCP-ALL) is currently treated by
risk-adapted intensive chemotherapy•Genome-wide genomic analyses have uncovered the …

To characterize the incidence, clinical features and genetics of ETV6-ABL1 leukemias,
representing targetable kinase-activating lesions, we analyzed 44 new and published cases …

To obtain a comprehensive picture of composite genetic driver events and clonal dynamics
in subtypes of paediatric acute lymphoblastic leukaemia (ALL) we analysed tumour-normal …

Recurrent and clonal genetic alterations are characteristic of different subtypes of T-and B-
cell lymphoblastic leukemia (ALL), and several subtypes are strong independent predictors …

Somatic mutations in cancer cells may influence tumor growth, survival, or immune
interactions in their microenvironment. The tumor necrosis factor receptor family member …

The aim of this study was to determine the association between polymorphisms in gene
encoding B-and T-lymphocyte attenuator (BTLA) and susceptibility to chronic lymphocytic …

Intragenic deletion of IKZF1 is a recurrent genomic alteration in acute lymphoblastic
leukemia. The deletions are mediated by illegitimate variable (diversity) joining …

El 75% de los pacientes con leucemia aguda linfoblástica (LAL) tiene alteraciones
cromosómicas recurrentes (numéricas o estructurales). Dichas anomalías (alteraciones …

Abstract ETV6-RUNX1, also known as TEL-AML1, is the most frequent chromosomal
translocation in childhood Acute Lymphoblastic Leukemia (ALL) with an incidence of …