PLK1 is an evolutionary conserved Ser/Thr kinase that is best known for its role in cell cycle
regulation and is expressed predominantly during the G2/S and M phase of the cell cycle …

Epithelia are robust tissues that support the structure of embryos and organs and serve as
effective barriers against pathogens. Epithelia also chemically separate different …

Endocytic recycling is coordinated with endocytic uptake to control the composition of the
plasma membrane. Although much of our understanding of endocytic recycling has come …

Polyploid giant cancer cells (PGCCs) have been observed by pathologists for over a
century. PGCCs contribute to solid tumor heterogeneity, but their functions are largely …

Cytokinesis, the final step in cell division, partitions the contents of a single cell into two. In
animal cells, cytokinesis occurs through cortical remodeling orchestrated by the anaphase …

Despite our rapidly growing knowledge about the human genome, we do not know all of the
genes required for some of the most basic functions of life. To start to fill this gap we …

The notion that cell shape and spreading can regulate cell proliferation has evolved over
several years, but only recently has this been linked to forces from within and upon the cell …

Mistakes during cell division frequently generate changes in chromosome content,
producing aneuploid or polyploid progeny cells. Polyploid cells may then undergo abnormal …

Cell division, the purpose of which is to enable cell replication, and in particular to distribute
complete, accurate copies of genetic material to daughter cells, is essential for the …

Formins are a widely expressed family of proteins that govern cell shape, adhesion,
cytokinesis, and morphogenesis by remodeling the actin and microtubule cytoskeletons …