Pervasive transcription: a controlled risk
T Villa, O Porrua - The FEBS Journal, 2023 - Wiley Online Library
Transcriptome‐wide interrogation of eukaryotic genomes has unveiled the pervasive nature
of RNA polymerase II transcription. Virtually, any DNA region with an accessible chromatin …
of RNA polymerase II transcription. Virtually, any DNA region with an accessible chromatin …
Operation of a TCA cycle subnetwork in the mammalian nucleus
E Kafkia, A Andres-Pons, K Ganter, M Seiler… - Science …, 2022 - science.org
Nucleic acid and histone modifications critically depend on the tricarboxylic acid (TCA) cycle
for substrates and cofactors. Although a few TCA cycle enzymes have been reported in the …
for substrates and cofactors. Although a few TCA cycle enzymes have been reported in the …
Diverse and dynamic forms of gene regulation by the S. cerevisiae histone methyltransferase Set1
N Deshpande, M Bryk - Current Genetics, 2023 - Springer
Gene transcription is an essential and highly regulated process. In eukaryotic cells, the
structural organization of nucleosomes with DNA wrapped around histone proteins impedes …
structural organization of nucleosomes with DNA wrapped around histone proteins impedes …
[HTML][HTML] The SET7 protein of Leishmania donovani moderates the parasite's response to a hostile oxidative environment
SET domain proteins methylate specific lysines on proteins, triggering stimulation or
repression of downstream processes. Twenty-nine SET domain proteins have been …
repression of downstream processes. Twenty-nine SET domain proteins have been …
Assessing the in vitro Binding Affinity of Protein–RNA Interactions Using an RNA Pull-down Technique
RNA is a vital component of the cell and is involved in a diverse range of cellular processes
through a variety of functions. However, many of these functions cannot be performed …
through a variety of functions. However, many of these functions cannot be performed …
Modulated termination of non-coding transcription partakes in the regulation of gene expression
N Haidara, M Giannini, O Porrua - Nucleic Acids Research, 2022 - academic.oup.com
Pervasive transcription is a universal phenomenon leading to the production of a plethora of
non-coding RNAs. If left uncontrolled, pervasive transcription can be harmful for genome …
non-coding RNAs. If left uncontrolled, pervasive transcription can be harmful for genome …
Profiling the compendium of changes in Saccharomyces cerevisiae due to mutations that alter availability of the main methyl donor S-Adenosylmethionine
MK Remines, MG Schoonover, Z Knox… - G3: Genes …, 2024 - academic.oup.com
The SAM1 and SAM2 genes encode for S-Adenosylmethionine (AdoMet) synthetase
enzymes, with AdoMet serving as the main cellular methyl donor. We have previously shown …
enzymes, with AdoMet serving as the main cellular methyl donor. We have previously shown …
[图书][B] Spt5 and the Pol II Stalk Collaborate to Regulate Co-transcriptional pre-mRNA processing
ZA Morton - 2022 - search.proquest.com
Transcription of DNA into mRNA by RNA Polymerase II (Pol II) is a highly dynamic and
complex process that requires the concurrent collaboration of many factors. One such factor …
complex process that requires the concurrent collaboration of many factors. One such factor …
[HTML][HTML] Using machine learning and targeted mass spectrometry to explore the methyl-lys proteome
Protein lysine methylation mediates a variety of biological processes, and their
dysregulation has been established to play pivotal roles in human disease. A number of …
dysregulation has been established to play pivotal roles in human disease. A number of …
Analyse du rôle de la terminaison de la transcription des ARN non-codants dans la régulation de l'expression des gènes
NEM Haidara - 2021 - theses.hal.science
La transcription pervasive est un phénomène universel et constitue une source importante
d'ARN non-codants. Elle peut s's' interférer avec l'expression normale des gènes …
d'ARN non-codants. Elle peut s's' interférer avec l'expression normale des gènes …