Techniques of assessing small airways dysfunction
W McNulty, OS Usmani - European clinical respiratory journal, 2014 - Taylor & Francis
The small airways are defined as those less than 2 mm in diameter. They are a major site of
pathology in many lung diseases, not least chronic obstructive pulmonary disease (COPD) …
pathology in many lung diseases, not least chronic obstructive pulmonary disease (COPD) …
Computed tomography: revolutionizing the practice of medicine for 40 years
GD Rubin - Radiology, 2014 - pubs.rsna.org
Computed tomography (CT) has had a profound effect on the practice of medicine. Both the
spectrum of clinical applications and the role that CT has played in enhancing the depth of …
spectrum of clinical applications and the role that CT has played in enhancing the depth of …
CT-definable subtypes of chronic obstructive pulmonary disease: a statement of the Fleischner Society
DA Lynch, JHM Austin, JC Hogg, PA Grenier… - Radiology, 2015 - pubs.rsna.org
The purpose of this statement is to describe and define the phenotypic abnormalities that
can be identified on visual and quantitative evaluation of computed tomographic (CT) …
can be identified on visual and quantitative evaluation of computed tomographic (CT) …
High-resolution chest computed tomography imaging of the lungs: impact of 1024 matrix reconstruction and photon-counting detector computed tomography
DJ Bartlett, CW Koo, BJ Bartholmai… - Investigative …, 2019 - journals.lww.com
Objectives The aim of this study was to evaluate if a high-resolution photon-counting
detector computed tomography (PCD-CT) system with a 1024× 1024 matrix reconstruction …
detector computed tomography (PCD-CT) system with a 1024× 1024 matrix reconstruction …
A 3D-CNN model with CT-based parametric response mapping for classifying COPD subjects
Chronic obstructive pulmonary disease (COPD) is a respiratory disorder involving
abnormalities of lung parenchymal morphology with different severities. COPD is assessed …
abnormalities of lung parenchymal morphology with different severities. COPD is assessed …
Quantitative computed tomographic imaging–based clustering differentiates asthmatic subgroups with distinctive clinical phenotypes
Background Imaging variables, including airway diameter, wall thickness, and air trapping,
have been found to be important metrics when differentiating patients with severe asthma …
have been found to be important metrics when differentiating patients with severe asthma …
Parametric response mapping monitors temporal changes on lung CT scans in the subpopulations and intermediate outcome measures in COPD Study (SPIROMICS)
JL Boes, BA Hoff, M Bule, TD Johnson, A Rehemtulla… - Academic radiology, 2015 - Elsevier
Rationale and Objectives The longitudinal relationship between regional air trapping and
emphysema remains unexplored. We have sought to demonstrate the utility of parametric …
emphysema remains unexplored. We have sought to demonstrate the utility of parametric …
Relationship between pulmonary matrix metalloproteinases and quantitative CT markers of small airways disease and emphysema in COPD
Background Matrix metalloproteinases (MMPs) are proteolytic enzymes that can degrade
the extracellular matrix and drive tissue remodelling, key processes in the pathogenesis of …
the extracellular matrix and drive tissue remodelling, key processes in the pathogenesis of …
Spirometric assessment of emphysema presence and severity as measured by quantitative CT and CT-based radiomics in COPD
M Occhipinti, M Paoletti, BJ Bartholmai… - Respiratory …, 2019 - Springer
Background The mechanisms underlying airflow obstruction in COPD cannot be
distinguished by standard spirometry. We ascertain whether mathematical modeling of …
distinguished by standard spirometry. We ascertain whether mathematical modeling of …
Fleischner Society visual emphysema CT patterns help predict progression of emphysema in current and former smokers: results from the COPDGene study
B El Kaddouri, MJ Strand, D Baraghoshi… - Radiology, 2021 - pubs.rsna.org
Background The correlation between visual emphysema patterns and subsequent
progression of disease may provide a way to enrich a study population for treatment trials of …
progression of disease may provide a way to enrich a study population for treatment trials of …