Obesity is a major risk for diabetes. Brown adipose tissue (BAT) mediates production of heat
while white adipose tissue (WAT) function in the storage of fat. Roles of BAT in the treatment …

Brown adipose tissue (BAT) is the major site of non-shivering thermogenesis and crucial for
systemic metabolism. Under chronic cold exposures and high-fat diet challenges, BAT …

Human brown adipose tissue (BAT) undergoes progressive involution. This involution
process is not recapitulated in rodents, and the underlying mechanisms are poorly …

Osteosarcoma is one of the most malignant cancer adolescents and young adults and
metastatic osteosarcoma is a huge life threat with a 5-year survival lower than 20 …

Metabolic inflexibility, defined as the inability to respond or adapt to metabolic demand, is
now recognised as a driving factor behind many pathologies associated with obesity and the …

Hematopoiesis is regulated by signals from the microenvironment, transcription factor
networks, and changes of the epigenetic landscape. Transcription factors interact with and …

Adipogenesis is regulated by a cascade of signals that drive transcriptional reprogramming
in adipocytes. Here, we report that nuclear actin regulates the chromatin states that establish …

Brown and beige fat share a remarkably similar transcriptional program that supports fuel
oxidation and thermogenesis. The chromatin-remodeling machinery that governs genome …

Prolonged cold exposure stimulates the recruitment of beige adipocytes within white
adipose tissue. Beige adipocytes depend on mitochondrial oxidative phosphorylation to …

Homeothermic vertebrates produce heat in cold environments through thermogenesis, in
which brown adipose tissue (BAT) increases mitochondrial oxidation along with uncoupling …