Regulatory T (Treg) cells require (interleukin-2) IL-2 for their homeostasis by affecting their
proliferation, survival and activation. Here we investigated transcriptional and epigenetic …

Multiple sclerosis (MS) is a T cell driven autoimmune disease of the central nervous system
(CNS). Despite its association with Epstein-Barr Virus (EBV), how viral infections promote …

Highlights•The γ c cytokines interleukin (IL)-2, IL-7, and IL-15 regulate immune cell
differentiation.•IL-2, IL-7, and IL-15 modulate naïve, effector, and memory CD4+ T-cell …

Inflammatory bowel disease (IBD) is characterized by chronic relapsing inflammatory
disorders of the gastrointestinal tract, and includes two major phenotypes: ulcerative colitis …

Endometriosis is a benign, chronic inflammatory disease that presents alterations in immune
response that can be detected in eutopic endometrium, peritoneal fluid and peripheral blood …

Therapeutic options for metastatic colorectal cancer (mCRC) are very limited, and the
prognosis using combination therapy with a chemotherapeutic drug and a targeted agent …

Hypertension is a growing health concern worldwide. Established hypertension is a
causative factor of heart failure, which is characterized by increased vascular resistance and …

Natural compounds derived from medicinal plants have long been considered a rich source
of novel therapeutic agents. Baicalin (Ba) is a bioactive flavonoid compound derived from …

Simple Summary T cells bearing the co-receptor CD4 on their cell surface are a
heterogeneous group of T lymphocytes that exert pro-or anti-inflammatory functions …

Non-alcoholic fatty liver disease (NAFLD) is an increasing problem worldwide and is
associated with negative outcomes such as cirrhosis, hepatocellular carcinoma, insulin …