Identifying the design principles of complex regulatory networks driving cellular decision-
making remains essential to decode embryonic development as well as enhance cellular …

Sub-micron-sized silica nanoparticles, even as small as 10–20 nm in diameter, are well-
known for their activation of mononuclear phagocytes. In contrast, the cellular impact of …

Simple Summary The evolution of cancer is strongly influenced by the context in which
tumor cells develop and grow, known as the tumor microenvironment (TME). The TME is …

Retinoic-acid-receptor-related orphan nuclear receptor γt (RORγt) controls the transcription
of interleukin-17A (IL-17A), which plays critical roles in the pathogenesis of autoimmune …

Various disciplines cooperate to find novel approaches to cure impaired body functions by
repairing, replacing, or regenerating cells, tissues, or organs. The possibility that a stable …

Abstract Regulatory FOXP3+ T cells (Tregs) constitute 5% to 10% of T cells in the normal
human skin. They play an important role in the induction and maintenance of immunological …

Th1 lymphocytes are considered the main mediators of protection against tuberculosis (TB);
however, their phenotypic characteristics and relationship with Th17 and Th1Th17 …

For a long time asthma was commonly considered as a homogeneous disease. However,
recent studies provide increasing evidence of its heterogeneity and existence of different …

Lymphodepleting preconditioning with high-dose chemotherapy is commonly used to
increase the clinical efficacy of adoptive T cell therapy (ACT) strategies, however, with …

Abstract B cell lymphoma-6 (Bcl-6) is a transcriptional repressor that is required for the
differentiation of T follicular helper (T FH) cell populations. Currently, the molecular …