Challenges and Opportunities in the Crusade of BRAF Inhibitors: From 2002 to 2022
Serine/threonine-protein kinase B-Raf (BRAF; RAF= rapidly accelerated fibrosarcoma) plays
an important role in the mitogen-activated protein kinase (MAPK) signaling cascade …
an important role in the mitogen-activated protein kinase (MAPK) signaling cascade …
New Potential Agents for Malignant Melanoma Treatment—Most Recent Studies 2020–2022
P Kozyra, D Krasowska, M Pitucha - International Journal of Molecular …, 2022 - mdpi.com
Malignant melanoma (MM) is the most lethal skin cancer. Despite a 4% reduction in mortality
over the past few years, an increasing number of new diagnosed cases appear each year …
over the past few years, an increasing number of new diagnosed cases appear each year …
Novel pyridine-thiazolidinone-triazole hybrid glycosides targeting EGFR and CDK-2: Design, synthesis, anticancer evaluation, and molecular docking simulation
AF Kassem, MA Omar, ES Nossier, HM Awad… - Journal of Molecular …, 2023 - Elsevier
The observed toxicity of newly designed anticancer drugs is considered as an impediment
challenging phenomenon of intense concern arising from diversity in drug targets and the …
challenging phenomenon of intense concern arising from diversity in drug targets and the …
An updated literature on BRAF inhibitors (2018–2023)
BRAF is the most common serine-threonine protein kinase and regulates signal transduction
from RAS to MEK inside the cell. The BRAF is a highly active isoform of RAF kinase. BRAF …
from RAS to MEK inside the cell. The BRAF is a highly active isoform of RAF kinase. BRAF …
Synthesis, biological evaluation and molecular docking of new triphenylamine-linked pyridine, thiazole and pyrazole analogues as anticancer agents
A new series of pyridine, thiazole, and pyrazole analogues were synthesized. The pyridone
analogues 4a-e were synthesized by treating N-aryl-2-cyano-3-(4-(diphenylamino) phenyl) …
analogues 4a-e were synthesized by treating N-aryl-2-cyano-3-(4-(diphenylamino) phenyl) …
An overview of RAF kinases and their inhibitors (2019-2023)
OM Hashem, AI Shahin, MA Al Hindawi… - European Journal of …, 2024 - Elsevier
Protein kinases (PKs) including RAF, performs a principal role in regulating countless
cellular events such as cell growth, differentiation, and angiogenesis. Overexpression and …
cellular events such as cell growth, differentiation, and angiogenesis. Overexpression and …
Recent pharmacological insights about imidazole hybrids: a comprehensive review
In this review, we evaluated the biological activities of hybrid molecules incorporating
imidazoles—a cornerstone in medicinal chemistry known for their broad pharmacological …
imidazoles—a cornerstone in medicinal chemistry known for their broad pharmacological …
Pyridine-Based Glycosides Bearing 1, 2, 4-Triazole and Their 1, 3, 4-oxadiazole analogues as Potential EGFR and CDK-2 Inhibitors: Design, Synthesis …
AF Kassem, A Younis, ES Nossier, HM Awad… - Journal of Molecular …, 2024 - Elsevier
The increasing toxicity of recently developed anticancer medications is seen as a serious
problem that stems from the variety of targets involved; as a result, more research on these …
problem that stems from the variety of targets involved; as a result, more research on these …
Current Scenario of Pyridine/Quinoline-Sulfonamide Hybrids with Anticancer Potential (A Review)
GL Dong, YP Feng, JJ Wang, X Sun - Russian Journal of General …, 2024 - Springer
Cancer, which proliferates and spreads uncontrollably due to the accumulation of genetic
and epigenetic factors, is one of the most fatal diseases. Cancer management meets …
and epigenetic factors, is one of the most fatal diseases. Cancer management meets …