Design, synthesis, and anti-cancer evaluation of new pyrido [2, 3-d] pyrimidin-4 (3H)-one derivatives as potential EGFRWT and EGFRT790M inhibitors and apoptosis …
HSA Elzahabi, ES Nossier, RA Alasfoury… - Journal of Enzyme …, 2022 - Taylor & Francis
A new series of pyrido [2, 3-d] pyrimidin-4 (3H)-one derivatives having the essential
pharmacophoric features of EGFR inhibitors has been designed and synthesised. Cell …
pharmacophoric features of EGFR inhibitors has been designed and synthesised. Cell …
Discovery and antiproliferative evaluation of new quinoxalines as potential DNA intercalators and topoisomerase II inhibitors
In continuation of our previous work on the design and synthesis of topoisomerase II (Topo
II) inhibitors and DNA intercalators, a new series of quinoxaline derivatives were designed …
II) inhibitors and DNA intercalators, a new series of quinoxaline derivatives were designed …
Investigating the potential anticancer activities of antibiotics as topoisomerase II inhibitors and DNA intercalators: in vitro, molecular docking, molecular dynamics, and …
Abstract Topoisomerase II (TOP-2) is a promising molecular target for cancer therapy.
Numerous antibiotics could interact with biologically relevant macromolecules and provoke …
Numerous antibiotics could interact with biologically relevant macromolecules and provoke …
Synthesis, docking, QSAR, ADMET and antimicrobial evaluation of new quinoline-3-carbonitrile derivatives as potential DNA-gyrase inhibitors
KM El-Gamal, AM El-Morsy, AM Saad, IH Eissa… - Journal of Molecular …, 2018 - Elsevier
Novel sixty three quinoline-3-carbonitrile derivatives were synthesized starting from 6-
substituted-2-hydrazinyl quinoline-3-carbonitrile. The synthesized compounds were …
substituted-2-hydrazinyl quinoline-3-carbonitrile. The synthesized compounds were …
Design, synthesis, molecular modeling and anti-hyperglycemic evaluation of phthalimide-sulfonylurea hybrids as PPARγ and SUR agonists
MA El-Zahabi, ER Elbendary, FH Bamanie… - Bioorganic …, 2019 - Elsevier
New series of phthalimide-sulfonylurea hybrids were prepared and examined for their in
vivo anti-hyperglycemic activities in STZ-induced hyperglycemic rats using glibenclamide as …
vivo anti-hyperglycemic activities in STZ-induced hyperglycemic rats using glibenclamide as …
Discovery of new uracil and thiouracil derivatives as potential HDAC inhibitors
Background: Histone deacetylase inhibitors (HDACIs) are a relatively new class of potential
drugs for treating cancer. Aim: Discovery of new anticancer agents targeting HDAC …
drugs for treating cancer. Aim: Discovery of new anticancer agents targeting HDAC …
Design, synthesis and biological evaluation of novel benzo-and tetrahydrobenzo-[h] quinoline derivatives as potential DNA-intercalating antitumor agents
F Jafari, H Baghayi, P Lavaee, F Hadizadeh… - European journal of …, 2019 - Elsevier
A new series of benzo-and tetrahydro benzo-[h] quinoline bearing a flexible (dimethylamino)
ethylcarboxamide side chain was designed and synthesized as DNA-intercalating antitumor …
ethylcarboxamide side chain was designed and synthesized as DNA-intercalating antitumor …
Design, synthesis, anticancer activity and molecular docking studies of new benzimidazole derivatives bearing 1, 3, 4-oxadiazole moieties as potential thymidylate …
ASA Almalki, S Nazreen, SEI Elbehairi… - New Journal of …, 2022 - pubs.rsc.org
The present work describes the synthesis and anticancer activity of new benzimidazole
derivatives bearing 1, 3, 4-oxadiazoles as thymidylate synthase inhibitors. The newly …
derivatives bearing 1, 3, 4-oxadiazoles as thymidylate synthase inhibitors. The newly …
Design, synthesis, molecular docking and antiproliferative activity of some novel benzothiazole derivatives targeting EGFR/HER2 and TS
Multi-targeted anticancer drugs are in focus as a promising research topic. A new series of
benzothiazoles hybridized with pyrimidine moiety was designed and synthesized using the …
benzothiazoles hybridized with pyrimidine moiety was designed and synthesized using the …
Design, synthesis, biological evaluation and molecular modeling investigation of new N'-(2-Thiouracil-5-oyl) hydrazone derivatives as potential anti-breast cancer and …
AAS El-Etrawy, FF Sherbiny - Journal of Molecular Structure, 2021 - Elsevier
A series of novel N'-(2-thiouracil-5-oyl) hydrazones were designed and chemically
synthesized using an active substructure combination method. The synthesized compounds …
synthesized using an active substructure combination method. The synthesized compounds …