The role of gut dysbiosis in Parkinson's disease: mechanistic insights and therapeutic options

Q Wang, Y Luo, K Ray Chaudhuri, R Reynolds, EK Tan… - Brain, 2021 - academic.oup.com
Parkinson's disease is a common neurodegenerative disorder in which gastrointestinal
symptoms may appear prior to motor symptoms. The gut microbiota of patients with …

Microglia mediated neuroinflammation in Parkinson's disease

S Isik, B Yeman Kiyak, R Akbayir, R Seyhali, T Arpaci - Cells, 2023 - mdpi.com
Parkinson's Disease (PD) is the second most common neurodegenerative disorder seen,
especially in the elderly. Tremor, shaking, movement problems, and difficulty with balance …

The immunology of Parkinson's disease

B Zhu, D Yin, H Zhao, L Zhang - Seminars in immunopathology, 2022 - Springer
Parkinson's disease (PD) is the second most common neurodegenerative disorder which
affects 6.1 million people worldwide. The neuropathological hallmarks include the loss of …

Potential therapeutic use of the rosemary diterpene carnosic acid for Alzheimer's disease, Parkinson's disease, and long-COVID through NRF2 activation to counteract …

T Satoh, D Trudler, CK Oh, SA Lipton - Antioxidants, 2022 - mdpi.com
Rosemary (Rosmarinus officinalis [family Lamiaceae]), an herb of economic and gustatory
repute, is employed in traditional medicines in many countries. Rosemary contains carnosic …

Copper induces microglia-mediated neuroinflammation through ROS/NF-κB pathway and mitophagy disorder

Q Zhou, Y Zhang, L Lu, H Zhang, C Zhao, Y Pu… - Food and Chemical …, 2022 - Elsevier
The epidemiological correlation between copper exposure and higher risk of Parkinson
disease (PD) has been recognized for a long time, and microglia-mediated …

Corynoxine protects dopaminergic neurons through inducing autophagy and diminishing neuroinflammation in rotenone-induced animal models of Parkinson's …

L Chen, Y Huang, X Yu, J Lu, W Jia, J Song… - Frontiers in …, 2021 - frontiersin.org
Recent studies have shown that impairment of autophagy is related to the pathogenesis of
Parkinson's disease (PD), and small molecular autophagy enhancers are suggested to be …

Kaemperfol alleviates pyroptosis and microglia-mediated neuroinflammation in Parkinson's disease via inhibiting p38MAPK/NF-κB signaling pathway

M Cai, W Zhuang, E Lv, Z Liu, Y Wang, W Zhang… - Neurochemistry …, 2022 - Elsevier
The study aims to investigate whether kaemperfol (KAE) inhibits microglia pyroptosis and
subsequent neuroinflammatory response to exert neuroprotective effects, along with the …

Oxidative stress and neuroinflammation potentiate each other to promote progression of dopamine neurodegeneration

J He, G Zhu, G Wang, F Zhang - Oxidative medicine and …, 2020 - Wiley Online Library
Parkinson's disease (PD) is a chronic and complex disease of the central nervous system
(CNS). Progressive loss of dopamine (DA) neurons in midbrain substantia nigra is …

Ferritinophagy‐mediated ferroptosis involved in paraquat‐induced neurotoxicity of dopaminergic neurons: implication for neurotoxicity in PD

Y Zuo, J Xie, X Li, Y Li, A Thirupathi… - Oxidative medicine …, 2021 - Wiley Online Library
Parkinson's disease (PD) is a progressive nervous system disorder. Until now, the molecular
mechanism of its occurrence is not fully understood. Paraquat (PQ) was identified as a …

Pharmacological targeting of microglial activation: new therapeutic approach

CY Liu, X Wang, C Liu, HL Zhang - Frontiers in Cellular Neuroscience, 2019 - frontiersin.org
Mounting evidence suggests that neuroinflammation is not just a consequence but a vital
contributor to the development and progression of Parkinson's disease (PD). Microglia in …