Epithelial barrier dysfunction in chronic respiratory diseases
FM Carlier, C de Fays, C Pilette - Frontiers in physiology, 2021 - frontiersin.org
Mucosal surfaces are lined by epithelial cells, which provide a complex and adaptive
module that ensures first-line defense against external toxics, irritants, antigens, and …
module that ensures first-line defense against external toxics, irritants, antigens, and …
Machine learning in radiology: the new frontier in interstitial lung diseases
H Barnes, SM Humphries, PM George… - The Lancet Digital …, 2023 - thelancet.com
Challenges for the effective management of interstitial lung diseases (ILDs) include
difficulties with the early detection of disease, accurate prognostication with baseline data …
difficulties with the early detection of disease, accurate prognostication with baseline data …
Discovery of an Oxycyclohexyl Acid Lysophosphatidic Acid Receptor 1 (LPA1) Antagonist BMS-986278 for the Treatment of Pulmonary Fibrotic Diseases
PTW Cheng, RF Kaltenbach III, H Zhang… - Journal of Medicinal …, 2021 - ACS Publications
The oxycyclohexyl acid BMS-986278 (33) is a potent lysophosphatidic acid receptor 1
(LPA1) antagonist, with a human LPA1 K b of 6.9 nM. The structure–activity relationship …
(LPA1) antagonist, with a human LPA1 K b of 6.9 nM. The structure–activity relationship …
Mortality and survival in idiopathic pulmonary fibrosis: a systematic review and meta-analysis
Background There are substantial advances in diagnosis and treatment for idiopathic
pulmonary fibrosis (IPF), but without much evidence available on recent mortality and …
pulmonary fibrosis (IPF), but without much evidence available on recent mortality and …
Survival of adults with rheumatoid arthritis associated interstitial lung disease-A systematic review and meta-analysis
HJ Farquhar, N Beckert, L Beckert, AL Edwards… - Seminars in Arthritis and …, 2023 - Elsevier
Background Rheumatoid arthritis associated interstitial lung disease (RA-ILD) is associated
with high levels of morbidity and mortality. The primary aim of this systematic review was to …
with high levels of morbidity and mortality. The primary aim of this systematic review was to …
Targeting monocytes/macrophages in fibrosis and cancer diseases: Therapeutic approaches
E Conte - Pharmacology & Therapeutics, 2022 - Elsevier
Over almost 140 years since their identification, the knowledge about macrophages has
unbelievably evolved. The'big eaters' from being thought of as simple phagocytic cells have …
unbelievably evolved. The'big eaters' from being thought of as simple phagocytic cells have …
Zinpentraxin alfa for idiopathic pulmonary fibrosis: the randomized phase III STARSCAPE trial
L Richeldi, C Schiffman, J Behr, Y Inoue… - American Journal of …, 2024 - atsjournals.org
Rationale: A phase II trial reported clinical benefit over 28 weeks in patients with idiopathic
pulmonary fibrosis (IPF) who received zinpentraxin alfa. Objectives: To investigate the …
pulmonary fibrosis (IPF) who received zinpentraxin alfa. Objectives: To investigate the …
Lung microbiome in idiopathic pulmonary fibrosis and other interstitial lung diseases
Interstitial lung diseases represent a heterogeneous and wide group of diseases in which
factors leading to disease initiation and progression are not fully understood. Recent …
factors leading to disease initiation and progression are not fully understood. Recent …
TGFβ1-RCN3-TGFBR1 loop facilitates pulmonary fibrosis by orchestrating fibroblast activation
M Wu, Z Wang, X Shi, D Zan, H Chen, S Yang… - Respiratory …, 2023 - Springer
Background Idiopathic pulmonary fibrosis (IPF) bears high mortality due to unclear
pathogenesis and limited therapeutic options. Therefore, identifying novel regulators is …
pathogenesis and limited therapeutic options. Therefore, identifying novel regulators is …
Incidence and prognostic significance of hypoxemia in fibrotic interstitial lung disease: an international cohort study
YH Khor, L Gutman, NA Hussein, KA Johannson… - Chest, 2021 - Elsevier
Background Hypoxemia is a cardinal feature of fibrotic interstitial lung disease (ILD). The
incidence, progression, and prognostic significance of hypoxemia in patients with fibrotic ILD …
incidence, progression, and prognostic significance of hypoxemia in patients with fibrotic ILD …