Mucosal surfaces are lined by epithelial cells, which provide a complex and adaptive
module that ensures first-line defense against external toxics, irritants, antigens, and …

Challenges for the effective management of interstitial lung diseases (ILDs) include
difficulties with the early detection of disease, accurate prognostication with baseline data …

The oxycyclohexyl acid BMS-986278 (33) is a potent lysophosphatidic acid receptor 1
(LPA1) antagonist, with a human LPA1 K b of 6.9 nM. The structure–activity relationship …

Background There are substantial advances in diagnosis and treatment for idiopathic
pulmonary fibrosis (IPF), but without much evidence available on recent mortality and …

Background Rheumatoid arthritis associated interstitial lung disease (RA-ILD) is associated
with high levels of morbidity and mortality. The primary aim of this systematic review was to …

Over almost 140 years since their identification, the knowledge about macrophages has
unbelievably evolved. The'big eaters' from being thought of as simple phagocytic cells have …

Rationale: A phase II trial reported clinical benefit over 28 weeks in patients with idiopathic
pulmonary fibrosis (IPF) who received zinpentraxin alfa. Objectives: To investigate the …

Interstitial lung diseases represent a heterogeneous and wide group of diseases in which
factors leading to disease initiation and progression are not fully understood. Recent …

Background Idiopathic pulmonary fibrosis (IPF) bears high mortality due to unclear
pathogenesis and limited therapeutic options. Therefore, identifying novel regulators is …

Background Hypoxemia is a cardinal feature of fibrotic interstitial lung disease (ILD). The
incidence, progression, and prognostic significance of hypoxemia in patients with fibrotic ILD …