Flavonoids: A myth or a reality for cancer therapy?

C Forni, M Rossi, I Borromeo, G Feriotto, G Platamone… - Molecules, 2021 - mdpi.com
Nutraceuticals are biologically active molecules present in foods; they can have beneficial
effects on health, but they are not available in large enough quantities to perform this …

Current understanding of flavonoids in cancer therapy and prevention

M Farhan, A Rizvi, M Aatif, A Ahmad - Metabolites, 2023 - mdpi.com
Cancer is a major cause of death worldwide, with multiple pathophysiological
manifestations. In particular, genetic abnormalities, inflammation, bad eating habits …

New insight into the management of renal excretion and hyperuricemia: Potential therapeutic strategies with natural bioactive compounds

B Yang, M Xin, S Liang, X Xu, T Cai, L Dong… - Frontiers in …, 2022 - frontiersin.org
Hyperuricemia is the result of increased production and/or underexcretion of uric acid.
Hyperuricemia has been epidemiologically associated with multiple comorbidities, including …

Chrysin ameliorates synovitis and fibrosis of osteoarthritic fibroblast-like synoviocytes in rats through PERK/TXNIP/NLRP3 signaling

L Ding, T Liao, N Yang, Y Wei, R Xing, P Wu… - Frontiers in …, 2023 - frontiersin.org
Objective: Synovitis and fibrosis are common pathological features of knee osteoarthritis
(KOA). The interaction of synovitis and fibrosis can promote KOA progression. Chrysin …

Thioredoxin-interacting protein (TXNIP) as a target for Alzheimer's disease: Flavonoids and phenols

M Zhang, G Hu, N Shao, Y Qin, Q Chen, Y Wang… - …, 2021 - Springer
Alzheimer's disease (AD) is a neurodegenerative disease characterized by amyloid plaques
and tangles that have become the fifth leading cause of death worldwide. Previous studies …

Effects of Herbs and Derived Natural Products on Lipopolysaccharide‐Induced Toxicity: A Literature Review

M Kianmehr, M Behdadfard… - Oxidative Medicine …, 2023 - Wiley Online Library
Introduction. Oxidative stress (OS) during inflammation can increase inflammatory
responses and damage tissue. Lipopolysaccharide (LPS) can induce oxidative stress and …

Heme oxygenase-1 ameliorates endotoxin-induced acute lung injury by modulating macrophage polarization via inhibiting TXNIP/NLRP3 inflammasome activation

X Wu, L Wu, Y Wu, W Chen, J Chen, L Gong… - Free Radical Biology and …, 2023 - Elsevier
Acute lung injury (ALI) remains a global public health issue without specific and effective
treatment options available in the clinic. Alveolar macrophage polarization is involved in the …

Pinelliae rhizoma alleviated acute lung injury induced by lipopolysaccharide via suppressing endoplasmic reticulum stress-mediated NLRP3 inflammasome

N Wang, X Zhang, P Shen, C Huang, H Deng… - Frontiers in …, 2022 - frontiersin.org
Pinelliae rhizoma (PR), one kind of commonly-used Chinese herbs, is generally prescribed
to treat various respiratory diseases, including acute lung injury (ALI). However, the accurate …

Cochlear Marginal Cell Pyroptosis Is Induced by Cisplatin via NLRP3 Inflammasome Activation

W Yu, S Zong, P Zhou, J Wei, E Wang, R Ming… - Frontiers in …, 2022 - frontiersin.org
Better understanding the mechanism of cisplatin-induced ototoxicity is of great significance
for clinical prevention and treatment of cisplatin-related hearing loss. However, the …

Chrysophanol alleviates acute lung injury caused by Klebsiella pneumoniae infection by inhibiting pro‐inflammatory cytokine production

F Jiang, J Jiang, W He, G Dong, N Xu… - Phytotherapy …, 2023 - Wiley Online Library
Acute lung injury (ALI) caused by acute bacterial infection remains a common life‐
threatening lung disease. An increased inflammatory response is the basis for the …