Astrocytes and inflammatory T helper cells: a dangerous liaison in multiple sclerosis

M Kunkl, C Amormino, V Tedeschi, MT Fiorillo… - Frontiers in …, 2022 - frontiersin.org
Multiple Sclerosis (MS) is a neurodegenerative autoimmune disorder of the central nervous
system (CNS) characterized by the recruitment of self-reactive T lymphocytes, mainly …

Autoreactive lymphocytes in multiple sclerosis: Pathogenesis and treatment target

R Liu, S Du, L Zhao, S Jain, K Sahay… - Frontiers in …, 2022 - frontiersin.org
Multiple sclerosis (MS) is a chronic inflammatory disease of the central nervous system
(CNS) characterized by destruction of the myelin sheath structure. The loss of myelin leads …

CD8+ T cells recognizing a neuron-restricted antigen injure axons in a model of multiple sclerosis

BDS Clarkson, EM Grund… - The Journal of …, 2023 - Am Soc Clin Investig
CD8+ T cells outnumber CD4+ cells in multiple sclerosis (MS) lesions associated with
disease progression, but the pathogenic role and antigenic targets of these clonally …

[HTML][HTML] Diagnostic and prognostic value of the RUNXOR/RUNX1 axis in multiple sclerosis

SFA Haridy, NN Shahin, MI Shabayek, MM Selim… - Neurobiology of …, 2023 - Elsevier
The runt-related transcription factor-1 (RUNX1) gene with its lncRNA RUNXOR are recently
becoming a research focus in various diseases, specifically immune-related diseases as …

Epstein–Barr virus infection, B‐cell dysfunction and other risk factors converge in gut‐associated lymphoid tissue to drive the immunopathogenesis of multiple …

J Leffler, S Trend, PH Hart… - Clinical & Translational …, 2022 - Wiley Online Library
Multiple sclerosis is associated with Epstein–Barr virus (EBV) infection, B‐cell dysfunction,
gut dysbiosis, and environmental and genetic risk factors, including female sex. A disease …

The blood–brain barrier—A key player in multiple sclerosis disease mechanisms

TG Schreiner, C Romanescu, BO Popescu - Biomolecules, 2022 - mdpi.com
Over the past decade, multiple sclerosis (MS), a chronic neuroinflammatory disease with
severe personal and social consequences, has undergone a steady increase in incidence …

[HTML][HTML] Biological aging of CNS-resident cells alters the clinical course and immunopathology of autoimmune demyelinating disease

JR Atkinson, AD Jerome, AR Sas, A Munie, C Wang… - JCI insight, 2022 - ncbi.nlm.nih.gov
Biological aging is the strongest factor associated with the clinical phenotype of multiple
sclerosis (MS). Relapsing-remitting MS typically presents in the third or fourth decade …

Emerging role of extracellular vesicles in multiple sclerosis: From cellular surrogates to pathogenic mediators and beyond

PL Palacio, ML Pleet, E Reátegui… - Journal of …, 2023 - Elsevier
Multiple Sclerosis (MS) is a chronic, inflammatory demyelinating disease of the central
nervous system (CNS) driven by a complex interplay of genetic and environmental factors …

Accumulation of pTreg cells is detrimental in late‐onset (aged) mouse model of multiple sclerosis

W Wang, R Thomas, J Oh, DM Su - Aging Cell, 2022 - Wiley Online Library
Although typically associated with onset in young adults, multiple sclerosis (MS) also attacks
the elderly, which is termed late‐onset MS. The disease can be recapitulated and studied in …

Mechanistic and biomarker studies to demonstrate immune tolerance in multiple sclerosis

MJ Docampo, A Lutterotti, M Sospedra… - Frontiers in …, 2022 - frontiersin.org
The induction of specific immunological tolerance represents an important therapeutic goal
for multiple sclerosis and other autoimmune diseases. Sound knowledge of the target …