Drug-induced nephrotoxicity is still a significant obstacle in pharmacotherapy of various
diseases and it accounts for around 25% of serious side-effects reported after drug …

Cisplatin is a highly effective chemotherapeutic agent that has been used for more than 50
years for a variety of cancers; however, its use is limited by toxicity, including nephrotoxicity …

Fisetin (FST), a natural flavonoid compound derived from various fruits and vegetables,
including apple, strawberry, and onion, demonstrates potential for a wide range of …

Purpose The present study aimed to investigate whether baicalein improves the sensitivity of
resistant ovarian cancer cells to cisplatin. Methods Transcriptomic sequencing and …

Cyclophosphamide, an oxazaphosphorine prodrug is frequently used in treatment of
neuroblastoma, which is one of the most prevalent solid organ malignancies in infants and …

Cisplatin is one of the most used chemotherapeutic agents nowadays. However, it presents
several and severe side effects. For that, the synthesis of new analogues of cisplatin is …

Allogeneic hematopoietic cell transplantation (HCT) offers cure for some patients with
hematological diseases but is associated with significant risk of morbidity and mortality. We …

Despite the investment in platinum drugs research, cisplatin, carboplatin and oxaliplatin are
still the only Pt-based compounds used as first line treatments for several cancers, with a few …

Kidney disease in cancer patients requires specialized evaluation for timely and accurate
diagnosis. A new Nephrology subspecialty—Onco-Nephrology—focuses on managing …

The immunosuppressant cyclosporine A (CSA) has been linked to serious renal toxic effects.
Although 2-methoxyestradiol (2ME) possesses a wide range of pharmacological abilities, it …