Radiation therapy (RT) is a curative treatment for many malignancies and provides effective
palliation in patients with tumor‐related symptoms. However, the biophysical effects of RT …

Radiation-induced lung injury (RILI) encompasses any lung toxicity induced by radiation
therapy (RT) and manifests acutely as radiation pneumonitis and chronically as radiation …

Transforming growth factor-beta (TGF-β) signaling regulates a wide range of biological
processes. TGF-β plays an important role in tumorigenesis and contributes to the hallmarks …

This report provides a review of early and late effects of radiation in normal tissues and
organs with respect to radiation protection. It was instigated following a recommendation in …

Acute radiation damage is most prominent in tissues with rapidly proliferating cells, such as
in epithelial surfaces of the skin or alimentary tract. Symptoms develop when functional cells …

Purpose: To identify a clinically relevant and available parameter upon which to identify non-
small cell lung cancer (NSCLC) patients at risk for pneumonitis when treated with three …

Radiation fibrosis is a frequent sequel of therapeutic or accidental radiation overexposure in
normal human tissues. One of the main fundamental problems yet unsolved in fibrotic …

Although radiotherapy improves locoregional control and survival in patients with non-small-
cell lung cancer, radiation pneumonitis is a common treatment-related toxicity. Many …

Introduction. The risk of developing side effects after radiotherapy is not only dependent on
radiation dose, but may also be affected by patient-related risk factors. Here we perform a …

Radiation pneumonitis and subsequent radiation pulmonary fibrosis are the two main dose-
limiting factors when irradiating the thorax that can have severe implications for patients' …