Proliferation and differentiation inside erythrocytes are important steps in the life cycle of
Plasmodium spp. To achieve these, the parasites export polypeptides to the surface of …

Abstract Development of a malaria vaccine remains a critical priority to decrease clinical
disease and mortality and facilitate eradication. Accordingly, RTS, S, a protein-subunit …

Abstract Background Virus-like particles (VLPs) represent a significant advance in the
development of subunit vaccines, combining high safety and efficacy. Their particulate …

Background Malaria in pregnancy has major impacts on mother and child health. To
complement existing interventions, such as intermittent preventive treatment and use of …

Isolation of metastatic circulating tumor cells (CTCs) from cancer patients is of high value for
disease monitoring and molecular characterization. Despite the development of many new …

Placental malaria (PM) due to Plasmodium falciparum is a major cause of maternal, fetal
and infant mortality, but the mechanisms of pathogenesis and protective immunity are …

The increasing demand for recombinant vaccine antigens or immunotherapeutic molecules
calls into question the universality of current protein expression systems. Vaccine production …

Plasmodium falciparum reticulocyte-binding protein homolog 5 (PfRH5) is a leading asexual
blood-stage vaccine candidate for malaria. In preparation for clinical trials, a full-length …

In areas where Plasmodium falciparum transmission is endemic, clinical immunity against
malaria is progressively acquired during childhood and adults are usually protected against …

Placental malaria can have severe consequences for both mother and child and effective
vaccines are lacking. Parasite-infected red blood cells sequester in the placenta through …