[HTML][HTML] GluN2A and GluN2B N-Methyl-D-Aspartate receptor (NMDARs) subunits: their roles and therapeutic antagonists in neurological diseases
N-methyl-d-aspartate receptors (NMDARs) are ion channels that respond to the
neurotransmitter glutamate, playing a crucial role in the permeability of calcium ions and …
neurotransmitter glutamate, playing a crucial role in the permeability of calcium ions and …
[HTML][HTML] Glycine Transporter 1 Inhibitors: Predictions on Their Possible Mechanisms in the Development of Opioid Analgesic Tolerance
AR Galambos, ZT Papp, I Boldizsár, F Zádor, L Köles… - Biomedicines, 2024 - mdpi.com
The development of opioid tolerance in patients on long-term opioid analgesic treatment is
an unsolved matter in clinical practice thus far. Dose escalation is required to restore …
an unsolved matter in clinical practice thus far. Dose escalation is required to restore …
Novel alkyl-substituted 4-methoxy benzaldehyde thiosemicarbazones: Multi-target directed ligands for the treatment of Alzheimer's disease
M Varma, V Ugale, J Shaukat, M Hollmann… - European Journal of …, 2023 - Elsevier
Alzheimer's disease (AD) is a devastating neurodegenerative disorder affecting mental
ability and interrupts neurocognitive functions. Treating multifactorial conditions of AD with a …
ability and interrupts neurocognitive functions. Treating multifactorial conditions of AD with a …
Development of novel 9H-carbazole-4H-chromene hybrids as dual cholinesterase inhibitors for the treatment of Alzheimer's disease
N Sharon, VG Ugale, P Padmaja, D Lokwani… - Molecular Diversity, 2024 - Springer
Alzheimer's disease (AD) is a neurodegenerative disease affecting mental ability and
neurocognitive functions. Cholinesterase enzymes affect concentration of acetylcholine in …
neurocognitive functions. Cholinesterase enzymes affect concentration of acetylcholine in …
[HTML][HTML] Molecular Mechanisms of the Regulation of Liver Cytochrome P450 by Brain NMDA Receptors and via the Neuroendocrine Pathway—A Significance for New …
R Pukło, E Bromek, A Haduch… - International Journal of …, 2023 - mdpi.com
Recent investigations have highlighted the potential utility of the selective antagonist of the
NMDA receptor GluN2B subunit for addressing major depressive disorders. Our previous …
NMDA receptor GluN2B subunit for addressing major depressive disorders. Our previous …