G protein-coupled receptors (GPCRs) are the largest family of membrane-bound receptors
and also the targets of many drugs. Understanding of the functional significance of the wide …

The extracellular calcium-sensing receptor (CaSR) plays a major role in the maintenance of
a physiological serum ionized calcium (Ca2+) concentration by regulating the circulating …

G-protein-coupled receptors (GPCR) are involved in directly and indirectly controlling an
extraordinary variety of physiological functions. Their key roles in cellular communication …

The discovery of a G protein–coupled, calcium-sensing receptor (CaR) a decade ago and of
diseases caused by CaR mutations provided unquestionable evidence of the CaR's critical …

Compelling evidence of a cell surface receptor sensitive to extracellular calcium was
observed as early as the 1980s and was finally realized in 1993 when the calcium-sensing …

Составляя около 50% массы тела, соединительная ткань (СТ) является одним из
четырех основных типов ткани в традиционных классификациях (в дополнение к эпи …

ABSTRACT A contemporary view of hormone action at the transcriptional level requires
knowledge of the transcription factors including the hormone receptor that may bind to …

Familial Isolated Hyperparathyroidism: Clinical and Genetic... : Medicine Familial Isolated
Hyperparathyroidism: Clinical and Genetic Characteristics of 36 Kindreds : Medicine Log in or …

The calcium-sensing receptor (CaSR) plays a pivotal role in systemic calcium metabolism by
regulating parathyroid hormone secretion and urinary calcium excretion. The CaSR is …

The calcium-sensing receptor (CaSR) is a G-protein-coupled receptor that has an
extracellular bilobed venus flytrap domain (VFTD) predicted to contain five calcium (Ca2+) …