The development of refractory tumor cells limits therapeutic efficacy in cancer by activating
mechanisms that promote cellular proliferation, migration, invasion, metastasis, and survival …

Most hosts are infected with multiple parasites, and responses of the immune system to co-
occurring parasites may influence disease spread. Helminth infection can bias the host …

Drugs that are already clinically approved or experimentally tested for conditions other than
cancer, but are found to possess previously unrecognized cytotoxicity towards malignant …

Fenbendazole (FZ) is a benzimidazole carbamate drug with broad-spectrum antiparasitic
activity in humans and animals. The mechanism of action of FZ is associated with …

The laboratory rat, Rattus norvegicus, is within the order Rodentia and family Muridae. The
genus Rattus contains at least 56 species (retrieved January 28, 2014, from the Integrated …

Purpose We aimed to inhibit ovarian cancer (OC) development by interfering with
microtubule polymerization and inhibiting mTOR signaling. To achieve this, previously …

The human diseases caused by the fungal pathogens Cryptococcus neoformans and
Cryptococcus gattii are associated with high indices of mortality and toxic and/or cost …

Veterinary antibiotics may find their way into the aquatic environment through direct or
indirect pathways due to their widespread use. Fenbendazole is a benzimidazole …

Fenbendazole, a broad-spectrum anti-parasitic drug, can be a potential anti-tumor agent. In
this study, we synthesized and purified its derivative, analog 6, intending to achieve …

Background/Aims: To evaluate the anticancer activity of fenbendazole, a widely used
antihelminth with mechanisms of action that overlap with those of the hypoxia-selective …