Engineering mesoporous silica nanoparticles for drug delivery: where are we after two decades?
The present review details a chronological description of the events that took place during
the development of mesoporous materials, their different synthetic routes and their use as …
the development of mesoporous materials, their different synthetic routes and their use as …
Multidrug resistance in cancer: understanding molecular mechanisms, immunoprevention and therapeutic approaches
Cancer is one of the leading causes of death worldwide. Several treatments are available for
cancer treatment, but many treatment methods are ineffective against multidrug-resistant …
cancer treatment, but many treatment methods are ineffective against multidrug-resistant …
Exosome-mediated delivery of Cas9 ribonucleoprotein complexes for tissue-specific gene therapy of liver diseases
CRISPR-Cas9 gene editing has emerged as a powerful therapeutic technology, but the lack
of safe and efficient in vivo delivery systems, especially for tissue-specific vectors, limits its …
of safe and efficient in vivo delivery systems, especially for tissue-specific vectors, limits its …
CRISPR-based therapeutic genome editing: strategies and in vivo delivery by AAV vectors
The development of clustered regularly interspaced short-palindromic repeat (CRISPR)-
based biotechnologies has revolutionized the life sciences and introduced new therapeutic …
based biotechnologies has revolutionized the life sciences and introduced new therapeutic …
Spatiotemporal control of CRISPR/Cas9 gene editing
The clustered regularly interspaced short palindromic repeats (CRISPR)/associated protein
9 (CRISPR/Cas9) gene editing technology, as a revolutionary breakthrough in genetic …
9 (CRISPR/Cas9) gene editing technology, as a revolutionary breakthrough in genetic …
A proton‐activatable DNA‐based nanosystem enables co‐delivery of CRISPR/Cas9 and dnazyme for combined gene therapy
F Li, N Song, Y Dong, S Li, L Li, Y Liu… - Angewandte Chemie …, 2022 - Wiley Online Library
CRISPR/Cas9 is emerging as a platform for gene therapeutics, and the treatment efficiency
is expected to be enhanced by combination with other therapeutic agents. Herein, we report …
is expected to be enhanced by combination with other therapeutic agents. Herein, we report …
Codelivery of CRISPR-Cas9 and chlorin e6 for spatially controlled tumor-specific gene editing with synergistic drug effects
S Deng, X Li, S Liu, J Chen, M Li, SY Chew… - Science …, 2020 - science.org
Controlled release of CRISPR-Cas9 ribonucleoprotein (RNP) and codelivery with other
drugs remain a challenge. We demonstrate controlled release of CRISPR-Cas9 RNP and …
drugs remain a challenge. We demonstrate controlled release of CRISPR-Cas9 RNP and …
Rational design of poly (disulfide) s as a universal platform for delivery of CRISPR-Cas9 machineries toward therapeutic genome editing
J Guo, T Wan, B Li, Q Pan, H Xin, Y Qiu… - ACS Central …, 2021 - ACS Publications
We synthesized a series of poly (disulfide) s by ring-opening polymerization and
demonstrated that the copolymerization of monomer 1 containing diethylenetriamine …
demonstrated that the copolymerization of monomer 1 containing diethylenetriamine …
Development of CRISPR/Cas delivery systems for in vivo precision genome editing
Y Chen, Y Ping - Accounts of Chemical Research, 2023 - ACS Publications
Conspectus Clustered, regularly interspaced, short palindromic repeat (CRISPR)/associated
protein 9 (CRISPR/Cas9) is emerging as a powerful genome-editing tool, enabling precise …
protein 9 (CRISPR/Cas9) is emerging as a powerful genome-editing tool, enabling precise …
Delivery of CRISPR/Cas systems for cancer gene therapy and immunotherapy
The clustered, regularly interspaced, short palindromic repeats (CRISPR)/CRISPR-
associated protein (Cas) systems are efficient and versatile gene editing tools, which offer …
associated protein (Cas) systems are efficient and versatile gene editing tools, which offer …