Aggressive pituitary tumours and pituitary carcinomas

G Raverot, MD Ilie, H Lasolle, V Amodru… - Nature Reviews …, 2021 - nature.com
Although usually benign, anterior pituitary tumours occasionally exhibit aggressive
behaviour, with invasion of surrounding tissues, rapid growth, resistance to conventional …

An individualized approach to the management of Cushing disease

M Fleseriu, EV Varlamov, JM Hinojosa-Amaya… - Nature Reviews …, 2023 - nature.com
Cushing disease caused by an adrenocorticotropic hormone (ACTH)-secreting pituitary
corticotroph adenoma leads to hypercortisolaemia with high mortality due to metabolic …

Pasireotide in the personalized treatment of acromegaly

M Puig-Domingo, I Bernabéu, A Picó… - Frontiers in …, 2021 - frontiersin.org
The delay in controlling the disease in patients who do not respond to first-line treatment
with first generation somatostatin receptor ligands (first-generation SRLs) can be quantified …

Cushing's syndrome effects on the thyroid

RM Paragliola, A Corsello, G Papi… - International journal of …, 2021 - mdpi.com
The most known effects of endogenous Cushing's syndrome are the phenotypic changes
and metabolic consequences. However, hypercortisolism can exert important effects on …

Pituitary tumours: molecular and genetic aspects

SMC De Sousa, NF Lenders, LS Lamb… - Journal of …, 2023 - joe.bioscientifica.com
'Pituitary tumours' is an umbrella term for various tumours originating from different regions
of the hypothalamic–pituitary system. The vast majority of pituitary tumours are pituitary …

Efficacy and tolerability of somatostatin analogues according to gender in patients with neuroendocrine tumors

RM Ruggeri, I Aini, S Gay, EM Grossrubatscher… - Reviews in Endocrine …, 2024 - Springer
As the incidence of neuroendocrine tumors has been rising, gender differences in
epidemiology and clinical behavior have emerged, and interest into a gender-driven …

Biomarkers of response to treatment in acromegaly

L Kasuki, E Lamback, X Antunes… - Expert Review of …, 2024 - Taylor & Francis
Introduction Medical treatment of acromegaly is based in atrial and errorapproach. First-
generation somatostatin receptor ligands (fg-SRL) are prescribed as first-line medical …

Pituitary acting drugs: cabergoline and pasireotide

MR Gadelha, LE Wildemberg, I Shimon - Pituitary, 2022 - Springer
First-line treatment for Cushing´ s disease is transsphenoidal surgery. But in cases of
persistent or recurrent disease after surgery, contraindications to surgery, severe …

Digital quantification of somatostatin receptor subtype 2a immunostaining: a validation study

C Campana, PM van Koetsveld… - European Journal of …, 2022 - academic.oup.com
Objective The aim of this study was to develop an open-source and reproducible digital
quantitative analysis (DIA) of somatostatin receptor subtype 2a (SST2) staining in formalin …

Peptide receptor radionuclide therapy and primary brain tumors: an overview

A Cimini, M Ricci, F Russo, M Egidi, F Calabria… - Pharmaceuticals, 2021 - mdpi.com
Primary brain tumors (PBTs) are some of the most difficult types of cancer to treat, and
despite advancements in surgery, chemotherapy and radiotherapy, new strategies for the …