Hypertension and the eye

L Konstantinidis, Y Guex-Crosier - Current opinion in …, 2016 - journals.lww.com
Assessment of hypertensive retinopathy signs may convey additional prognostic information
on the risk of end-organ damage and may alert for urgent systemic management or even …

Deep learning of the retina enables phenome-and genome-wide analyses of the microvasculature

SM Zekavat, VK Raghu, M Trinder, Y Ye, S Koyama… - Circulation, 2022 - Am Heart Assoc
Background: The microvasculature, the smallest blood vessels in the body, has key roles in
maintenance of organ health and tumorigenesis. The retinal fundus is a window for human …

Regulation of the trafficking and the function of the metalloprotease ADAM10 by tetraspanins

J Saint-Pol, E Eschenbrenner, E Dornier… - Biochemical Society …, 2017 - portlandpress.com
By interacting directly with partner proteins and with one another, tetraspanins organize a
network of interactions referred to as the tetraspanin web. ADAM10 (A Disintegrin And …

Genome-wide association identifies novel ROP risk loci in a multiethnic cohort

X Li, LA Owen, KD Taylor, S Ostmo, YDI Chen… - Communications …, 2024 - nature.com
We conducted a genome-wide association study (GWAS) in a multiethnic cohort of 920 at-
risk infants for retinopathy of prematurity (ROP), a major cause of childhood blindness …

[HTML][HTML] Impact of arterial hypertension on the eye: a review of the pathogenesis, diagnostic methods, and treatment of hypertensive retinopathy

J Dziedziak, A Zaleska-Żmijewska… - … Medical Journal of …, 2022 - ncbi.nlm.nih.gov
The number of patients with arterial hypertension is continually increasing. Hypertension
can cause organ complications, called hypertension-mediated organ damage (HMOD). One …

A review on the extraction of quantitative retinal microvascular image feature

K Kipli, ME Hoque, LT Lim… - … methods in medicine, 2018 - Wiley Online Library
Digital image processing is one of the most widely used computer vision technologies in
biomedical engineering. In the present modern ophthalmological practice, biomarkers …

The genetics of retinopathy of prematurity: a model for neovascular retinal disease

R Swan, SJ Kim, JP Campbell, RVP Chan… - Ophthalmology …, 2018 - Elsevier
Topic Retinopathy of prematurity (ROP) is a proliferative retinal vascular disease in
premature infants and is a major cause of childhood blindness worldwide. In addition to …

A commonly occurring genetic variant within the NPLOC4–TSPAN10–PDE6G gene cluster is associated with the risk of strabismus

D Plotnikov, RL Shah, JN Rodrigues, PM Cumberland… - Human Genetics, 2019 - Springer
Strabismus refers to an abnormal alignment of the eyes leading to the loss of central
binocular vision. Concomitant strabismus occurs when the angle of deviation is constant in …

Fine-mapping of retinal vascular complexity loci identifies Notch regulation as a shared mechanism with myocardial infarction outcomes

A Villaplana-Velasco, M Pigeyre, J Engelmann… - Communications …, 2023 - nature.com
There is increasing evidence that the complexity of the retinal vasculature measured as
fractal dimension, Df, might offer earlier insights into the progression of coronary artery …

[HTML][HTML] Genome-wide association studies of retinal vessel tortuosity identify numerous novel loci revealing genes and pathways associated with ocular and …

M Tomasoni, MJ Beyeler, SO Vela, N Mounier… - Ophthalmology …, 2023 - Elsevier
Purpose To identify novel susceptibility loci for retinal vascular tortuosity, to better
understand the molecular mechanisms modulating this trait, and reveal causal relationships …