Fibroblast growth factor receptor 2 (FGFR2) is frequently activated by overexpression or
mutation, and an abnormal fibroblast growth factor (FGF)/FGFR signaling pathway is …

FGFs and their receptors (FGFRs) are critical for many biologic processes, including
angiogenesis, wound healing and tissue regeneration. Aberrations in FGFR signaling are …

Cholangiocarcinoma (CCA) is a refractory cancer with limited treatment options and poorly
understood molecular mechanisms underlying tumor development. The most effective …

Zika virus (ZIKV) is an emerging pathogen that can cause microcephaly and other
neurological defects in developing fetuses. The cellular response to ZIKV in the fetal brain is …

Abstract Fibroblast growth factor 2 (FGF2) is a pleiotropic protein engaged in the regulation
of key cellular processes in a wide spectrum of cells. FGF2 is an important object of basic …

Fibroblast growth factor receptors (FGFRs) are integral membrane proteins involved in
various biological processes including proliferation, migration and apoptosis. There are a …

Adenoid cystic carcinoma (ACC) is the second most common malignancy of the salivary
gland. Although characterized as an indolent tumor, ACC often leads to incurable metastatic …

Despite advanced diseases continuing to be associated with grim prognoses, the past
decade has witnessed the advent of several novel treatment options for cholangiocarcinoma …

Cancer cells merely exist in isolation; rather, they exist in an intricate microenvironment
composed of blood vessels, signalling molecules, immune cells, stroma, fibroblasts, and the …

The fibroblast growth factor receptor (FGFR) family receptor tyrosine kinase (RTK) includes
four structurally related members, termed as FGFR1, FGFR2, FGFR3, and FGFR4. Given its …