TNFAIP3 promotes ALDH-positive breast cancer stem cells through FGFR1/MEK/ERK pathway
W Feng, M Gao, M Yang, X Li, Z Gan, T Wu, Y Lin… - Medical Oncology, 2022 - Springer
Breast cancer stem cells (BCSCs) are a tiny population of self-renewing cells that may
contribute to cancer initiation, progression, and resistance to therapy in patients. In our prior …
contribute to cancer initiation, progression, and resistance to therapy in patients. In our prior …
High-yield site-specific conjugation of fibroblast growth factor 1 with monomethylauristatin e via cysteine flanked by basic residues
M Lobocki, M Zakrzewska, A Szlachcic… - Bioconjugate …, 2017 - ACS Publications
Site-specific conjugation is a leading trend in the development of protein conjugates,
including antibody–drug conjugates (ADCs), suitable for targeted cancer therapy. Here, we …
including antibody–drug conjugates (ADCs), suitable for targeted cancer therapy. Here, we …
[HTML][HTML] Functional FGFR4 Gly388Arg polymorphism contributes to cancer susceptibility: Evidence from meta-analysis
SW Xiong, J Ma, F Feng, W Fu, SR Shu, T Ma, C Wu… - Oncotarget, 2017 - ncbi.nlm.nih.gov
Fibroblast growth factor receptor 4 (FGFR4) is a member of receptor tyrosine kinase family. A
functional Gly388Arg (rs351855 G> A) polymorphism in FGFR4 gene causes a glycine-to …
functional Gly388Arg (rs351855 G> A) polymorphism in FGFR4 gene causes a glycine-to …
Selective FGFR inhibitor BGJ398 inhibits phosphorylation of AKT and STAT3 and induces cytotoxicity in sphere-cultured ovarian cancer cells
Epithelial ovarian cancer is the most aggressive and lethal among the gynecological
malignancies, which is often found disseminated to peritoneal cavity at the time of diagnosis …
malignancies, which is often found disseminated to peritoneal cavity at the time of diagnosis …
Lysosomal sequestration impairs the activity of the preclinical FGFR inhibitor PD173074
B Englinger, S Kallus, J Senkiv, A Laemmerer, P Moser… - Cells, 2018 - mdpi.com
Knowledge of intracellular pharmacokinetics of anticancer agents is imperative for
understanding drug efficacy as well as intrinsic and acquired cellular resistance …
understanding drug efficacy as well as intrinsic and acquired cellular resistance …
Structural alterations in human fibroblast growth factor receptors in carcinogenesis
DS Mikhaylenko, BY Alekseev, DV Zaletaev… - Biochemistry …, 2018 - Springer
Fibroblast growth factor (FGF) plays an important role in human embryogenesis,
angiogenesis, cell proliferation, and differentiation. Carcinogenesis is accompanied by …
angiogenesis, cell proliferation, and differentiation. Carcinogenesis is accompanied by …
Design, Synthesis and Biological Evaluation of 6-(2,6-Dichloro-3,5-dimethoxyphenyl)-4-substituted-1H-indazoles as Potent Fibroblast Growth Factor Receptor …
Z Zhang, D Zhao, Y Dai, M Cheng, M Geng, J Shen… - Molecules, 2016 - mdpi.com
Tyrosine kinase fibroblast growth factor receptor (FGFR), which is aberrant in various cancer
types, is a promising target for cancer therapy. Here we reported the design, synthesis, and …
types, is a promising target for cancer therapy. Here we reported the design, synthesis, and …
IBT-based quantitative proteomics identifies potential regulatory proteins involved in pigmentation of purple sea cucumber, Apostichopus japonicus
Sea cucumbers are an important economic species and exhibit high yield value among
aquaculture animals. Purple sea cucumbers are very rare and beautiful and have stable …
aquaculture animals. Purple sea cucumbers are very rare and beautiful and have stable …
[HTML][HTML] Enhanced expression of FGF19 predicts poor prognosis in patients with non-small cell lung cancer
J Chen, J Shao, A Shen, X Zhu, X Zhang… - Journal of Thoracic …, 2021 - ncbi.nlm.nih.gov
Background Lung cancer is one of the most common cancers and a leading cause of cancer-
related death worldwide. Although many treatment options exist for lung cancer, some …
related death worldwide. Although many treatment options exist for lung cancer, some …
Structural characterization of the interaction of the fibroblast growth factor receptor with a small molecule allosteric inhibitor
F Kappert, S Sreeramulu, HRA Jonker… - … A European Journal, 2018 - Wiley Online Library
The interaction of fibroblast growth factors (FGFs) with their fibroblast growth factor receptors
(FGFRs) are important in the signaling network of cell growth and development …
(FGFRs) are important in the signaling network of cell growth and development …