Fibroblast growth factor 1 (FGF1) and its receptors (FGFRs) regulate crucial biological
processes such as cell proliferation and differentiation. Aberrant activation of FGFRs by their …

Oncogenic gene fusions have been identified in many cancers, and many serve as
druggable targets for therapy. Fibroblast growth factor receptor (FGFR) gene aberration is …

Fibroblast growth factor receptor 1 (FGFR1) has become a potential target for the treatment
of cancer. Designing FGFR1-selective inhibitors remains fundamental to the development of …

Recent evidence suggests that T-box transcription factor brachyury plays an important role
in lung cancer development and progression. However, the mechanisms underlying …

The discovery of fibroblast growth factors (FGFs) and fibroblast growth factor receptors
(FGFRs) provided a profound new insight into physiological and metabolic functions. FGF …

Introduction: It remains challenging to treat squamous cell lung cancer (SCC) with limited
therapeutic options. However, recent breakthroughs in targeted therapies and …

Glioblastoma (GBM) is a malignant brain tumor that grows quickly, spreads widely, and is
resistant to treatment. Fibroblast growth factor receptor (FGFR) 1 is a receptor tyrosine …

由于基因扩增, 激活突变和致癌融合, 成纤维细胞生长因子(fibroblast growth factor, FGF)/FGFR
系统的失调经常发生在肿瘤中. 因此, FGF/FGFR 靶向治疗的发展是一些基础 …

Genomic alterations are commonly found in the signaling pathways of fibroblast growth
factor receptors (FGFRs). Although there is no selective FGFR inhibitors in market, several …

Pediatric spinal oligodendrogliomas are rare and aggressive tumors. They do not share the
same molecular features of adult oligodendroglioma, and no previous reports have …