基于片段的药物设计(FBDD) 方法是一种通过筛选碎片库得到苗头片段, 然后采用基于结构的
设计策略对苗头片段进行优化和改造获得先导化合物的研究. 其研究过程分为3 个部分: 1) …

Introduction In the past, targeted therapies have not shown positive results as they have
been used without adequate molecular selection of patients with biliary tract cancer (BTC) …

The fibroblast growth factor receptors play a crucial role in binding to fibroblast growth factor
and are involved in various pathological conditions. These receptors consist of an …

Designed for quick, everyday reference, Handbook of Targeted Cancer Therapy and
Immunotherapy: Gastrointestinal Cancer provides a practical overview of this rapidly …

Fibroblast growth factor receptor 4 (FGFR4) is a transmembrane receptor with ligand-
induced tyrosine kinase activity and is involved in various biological and pathological …

Background Fibroblast growth factor 2 (FGF 2) and FGF receptor 1 (FGFR 1) have been
investigated in different human neoplasms and were shown to play important roles in the …

Background: Till today cancer is still challenging to treat and needs more active therapeutic
approaches. Participation of complex multi-pathway cell propagation instrument is a …

Czynniki wzrostu fibroblastów (ang. fibroblast growth factors, FGF) oraz ich receptory (ang.
fibroblast growth factor receptor, FGFR) regulują kluczowe procesy zachodzące w …

Background: Fibroblast growth factors (FGFs) and their high affinity receptors (FGFRs) play a
major role in cell proliferation, differentiation, migration, and apoptosis. Aberrant FGFR …

Abnormal activation of kinases is associated with various types of human cancer. A
milestone approval of a small‐molecule kinase inhibitor (SMKI), imatinib, in 2001 for the …