Lung ventilation fluctuates widely with behavior but arterial PCO 2 remains stable. Under
normal conditions, the chemoreflexes contribute to PaCO 2 stability by producing small …

Autonomic nervous system adjustments to the heart and blood vessels are necessary for
mediating the cardiovascular responses required to meet the metabolic demands of working …

Central chemoreception traditionally refers to a change in ventilation attributable to changes
in CO 2/H+ detected within the brain. Interest in central chemoreception has grown …

Pulmonary structure and function change significantly between young adulthood and old
age. Elastic elements of the lung degenerate, parenchymal tissue is lost, alveolar ducts and …

During exercise by healthy mammals, alveolar ventilation and alveolar‐capillary diffusion
increase in proportion to the increase in metabolic rate to prevent PaCO2 from increasing …

We provide an updated review on the current understanding of breathing and sleep at high
altitude in humans. We conclude that:(1) progressive changes in pH initiated by the …

We assessed the contribution of carotid body chemoreceptors to the ventilatory response to
specific CNS hypercapnia in eight unanaesthetized, awake dogs. We denervated one …

Respiratory chemoreceptor activity encoding arterial Pco2 and Po2 is a critical determinant
of ventilation. Currently, the relative importance of several putative chemoreceptor …

Background: We have previously shown an increased incidence of intermittent hypoxemia
(IH) events in preterm infants with severe retinopathy of prematurity (ROP). Animal models …

Background Novel treatments targeting in baroreflex sensitivity (BRS) and chemoreflex
sensitivity (CRS) heart failure (HF) are grounded on small prognostic studies, partly …