Following the discovery of the involvement of the ribonucleoprotein TDP‐43 in amyotrophic
lateral sclerosis (ALS) and frontotemporal lobar degeneration (FTLD), a major research …

The mitochondria‐targeting drugs can be conventionally divided into the following groups:
those compensating for the energy deficit involved in neurodegeneration, including …

Uncontrolled microglial activation is pivotal to the pathogenesis of Parkinson's disease (PD),
which can secrete Cathepsin L (CTSL) to affect the survival of neurons in the PD patients; …

A new series of conjugates of aminoadamantane and γ-carboline, which are basic scaffolds
of the known neuroactive agents, memantine and dimebon (Latrepirdine) was synthesized …

Literature data and authors' own results on the role of serine hydrolases,
acetylcholinesterase (AChE) and butyrylcholinesterase (BChE), as drug targets for treatment …

A strategy for the design of potential drugs for the treatment of neurodegenerative diseases
is considered. This strategy is based on multipharmacophore compounds combining several …

Alzheimer's disease (AD) is a multifactorial neurodegenerative process whose effective
treatment will require drugs that can act simultaneously on multiple pathogenic targets …

We studied the inhibitory activity of methylene blue (MB) γ-carbolines (gC) conjugates (MB-
gCs) against human erythrocyte acetylcholinesterase (AChE), equine serum …

Alzheimer's disease (AD) remains the most common neurodegenerative disease
characterized by β-amyloid protein (Aβ) deposition and memory loss. Studies have shown …

Because of the failure of all amyloid-β directed treatment strategies for Alzheimer's disease
(AD), the concept of mitochondrial dysfunction as a major pathomechanism of the cognitive …