[HTML][HTML] Anxiety and Alzheimer's disease pathogenesis: focus on 5-HT and CRF systems in 3xTg-AD and TgF344-AD animal models

NC Reyna, BJ Clark, DA Hamilton… - Frontiers in Aging …, 2023 - frontiersin.org
Dementia remains one of the leading causes of morbidity and mortality in older adults.
Alzheimer's disease (AD) is the most common type of dementia, affecting over 55 million …

[HTML][HTML] Survival Bias, Non-Lineal Behavioral and Cortico-Limbic Neuropathological Signatures in 3xTg-AD Mice for Alzheimer's Disease from Premorbid to Advanced …

A Muntsant, MM Castillo-Ruiz… - International journal of …, 2023 - mdpi.com
Pre-clinical research in aging is hampered by the scarcity of studies modeling its
heterogeneity and complexity forged by pathophysiological conditions throughout the life …

Putative pathological mechanisms of late-life depression and Alzheimer's disease

SMN Hasan, C Clarke, T Strand, FR Bambico - Brain Research, 2023 - Elsevier
Alzheimer's disease (AD) is a neurodegenerative disorder that is characterized by
progressive impairment in cognition and memory. AD is accompanied by several …

[HTML][HTML] Unravelling the complexities of depression with medical intelligence: exploring the interplay of genetics, hormones, and brain function

MBB Heyat, F Akhtar, F Munir, A Sultana… - Complex & Intelligent …, 2024 - Springer
Depression is a multifactorial disease with unknown etiology affecting globally. It's the
second most significant reason for infirmity in 2020, affecting about 50 million people …

Imbalance of multiple neurotransmitter pathways leading to depression-like behavior and cognitive dysfunction in the triple transgenic mouse model of Alzheimer …

M Zhang, L Liu, Y Xu, W Wang, N Qiu, F Zhang… - Metabolic Brain …, 2023 - Springer
Depression is among the most frequent psychiatric comorbid conditions in Alzheimer
disease (AD). However, pharmacotherapy for depressive disorders in AD is still a big …

Notopterol improves cognitive dysfunction and depression-like behavior via inhibiting STAT3/NF-ĸB pathway mediated inflammation in glioma-bearing mice

Z Zhou, Y Zhou, Z Huang, M Wang, J Jiang… - International …, 2023 - Elsevier
Over the past few decades, clinicians and experts applied kinds of therapies for patients with
malignant gliomas such as chemotherapy, radiation or surgical extraction. However, they …

[HTML][HTML] Temporal Appearance of Enhanced Innate Anxiety in Alzheimer Model Mice

A Szabó, S Farkas, C Fazekas, P Correia, T Chaves… - Biomedicines, 2023 - mdpi.com
The prevalence of Alzheimer's disorder (AD) is increasing worldwide, and the co-morbid
anxiety is an important, albeit often neglected problem, which might appear early during …

Mitochondrial calcium uniporter knockdown in hippocampal neurons alleviates anxious and depressive behavior in the 3XTG Alzheimer's disease mouse model

Y Wang, LH Wu, F Hou, ZJ Wang, MN Wu, C Hölscher… - Brain Research, 2024 - Elsevier
Alzheimer's disease (AD) is a progressive and degenerative disorder accompanied by
emotional disturbance, especially anxiety and depression. More and more evidence shows …

[HTML][HTML] The Dopaminergic Cells in the Median Raphe Region Regulate Social Behavior in Male Mice

T Chaves, B Török, CL Fazekas, P Correia… - International Journal of …, 2024 - mdpi.com
According to previous studies, the median raphe region (MRR) is known to contribute
significantly to social behavior. Besides serotonin, there have also been reports of a small …

Use of Ordered Beta Regression Unveils Cognitive Flexibility Index and Longitudinal Cognitive Training Signatures in Normal and Alzheimer's Disease Pathological …

D Alveal-Mellado, L Giménez-Llort - Brain sciences, 2024 - mdpi.com
Generalized linear mixed models (GLMMs) are a cornerstone data analysis strategy in
behavioral research because of their robustness in handling non-normally distributed …