Most rheumatic and musculoskeletal diseases (RMDs) can be placed along a spectrum of
disorders, with autoinflammatory diseases (including monogenic systemic autoinflammatory …

Rheumatoid arthritis is a systemic autoimmune disease characterized by excess morbidity
and mortality from cardiovascular disease. Mechanisms linking rheumatoid arthritis and …

Although each autoimmune disease is associated with specific tissue or organ damage,
rheumatic diseases share a pro-inflammatory pattern that might increase cardiovascular risk …

Arterial stiffness is recognized mainly as an indicator of arteriosclerosis and a predictor of
cardiovascular events. Cardio-ankle vascular index (CAVI), which reflects arterial stiffness …

Cardiovascular disease associated with obesity and autoimmunity is the leading cause of
death in these populations and significant residual risk remains despite current treatment …

Objective Neutrophil infiltration into the synovial joint is a hallmark of rheumatoid arthritis
(RA), a disease characterised by progressive bone erosion. However, the mechanisms by …

Autoimmune rheumatic diseases are characterised by an abnormal immune system
response, complement activation, cytokines dysregulation and inflammation. In last years …

Rheumatoid arthritis (RA) patients have a 50% increased risk of cardiovascular (CV)-related
morbidity and mortality. This excess CV risk is closely linked to RA disease severity and …

Protein carbamoylation is a non-enzymatic post-translational modification that binds
isocyanic acid, which can be derived from the dissociation of urea or from the …

Autoimmune rheumatic diseases (AIRDs) with unknown etiology are increasing in incidence
and prevalence. Up to 5% of the population is affected. AIRDs include rheumatoid arthritis …