Interleukin‐31: The “itchy” cytokine in inflammation and therapy

A Datsi, M Steinhoff, F Ahmad, M Alam, J Buddenkotte - Allergy, 2021 - Wiley Online Library
The cytokine interleukin‐31 has been implicated in the pathophysiology of multiple atopic
disorders such as atopic dermatitis (AD), allergic rhinitis, and airway hyper‐reactivity. In AD …

Spotlight on microRNAs in allergy and asthma

J Weidner, S Bartel, A Kılıç, UM Zissler, H Renz… - Allergy, 2021 - Wiley Online Library
In past 10 years, microRNAs (miRNAs) have gained scientific attention due to their
importance in the pathophysiology of allergic diseases and their potential as biomarkers in …

Two phase 3 trials of lebrikizumab for moderate-to-severe atopic dermatitis

JI Silverberg, E Guttman-Yassky, D Thaçi… - … England Journal of …, 2023 - Mass Medical Soc
Background Lebrikizumab, a high-affinity IgG4 monoclonal antibody targeting interleukin-13,
prevents the formation of the interleukin-4Rα–interleukin-13Rα1 heterodimer receptor …

Efficacy and safety of upadacitinib in patients with moderate to severe atopic dermatitis: analysis of follow-up data from the measure up 1 and measure up 2 …

EL Simpson, KA Papp, A Blauvelt, CY Chu… - JAMA …, 2022 - jamanetwork.com
Importance Primary results from the Measure Up 1 and Measure Up 2 studies demonstrated
upadacitinib efficacy and safety through 16 weeks in patients with atopic dermatitis. Longer …

Efficacy and safety of lebrikizumab, a high-affinity interleukin 13 inhibitor, in adults with moderate to severe atopic dermatitis: a phase 2b randomized clinical trial

E Guttman-Yassky, A Blauvelt, LF Eichenfield… - JAMA …, 2020 - jamanetwork.com
Importance Interleukin 13 (IL-13) is a central pathogenic mediator driving multiple features of
atopic dermatitis (AD) pathophysiology. Objective To evaluate the efficacy and safety of …

[HTML][HTML] Neuroimmune communication regulating pruritus in atopic dermatitis

M Steinhoff, F Ahmad, A Pandey, A Datsi… - Journal of Allergy and …, 2022 - Elsevier
Atopic dermatitis (AD) is a common, chronic-relapsing inflammatory skin disease with
significant disease burden. Genetic and environmental trigger factors contribute to AD …

Efficacy and safety of lebrikizumab in combination with topical corticosteroids in adolescents and adults with moderate-to-severe atopic dermatitis: a randomized …

EL Simpson, M Gooderham, A Wollenberg… - JAMA …, 2023 - jamanetwork.com
Importance Lebrikizumab (LEB), a high-affinity monoclonal antibody targeting interleukin (IL)-
13, demonstrated efficacy and safety in patients with moderate-to-severe atopic dermatitis …

Single-cell transcriptomics combined with interstitial fluid proteomics defines cell type–specific immune regulation in atopic dermatitis

TB Rojahn, V Vorstandlechner, T Krausgruber… - Journal of Allergy and …, 2020 - Elsevier
Background Atopic dermatitis (AD) is the most common chronic inflammatory skin disease,
but its complex pathogenesis is only insufficiently understood, resulting in still limited …

Atopic dermatitis: pathomechanisms and lessons learned from novel systemic therapeutic options

T Bieber, AS Paller, K Kabashima… - Journal of the …, 2022 - Wiley Online Library
Atopic dermatitis (AD) is a chronic, heterogenous, inflammatory skin disorder associated
with a high skin‐related health burden, typically starting in childhood and often persisting …

[HTML][HTML] Th2 modulation of transient receptor potential channels: an unmet therapeutic intervention for atopic dermatitis

J Meng, Y Li, MJM Fischer, M Steinhoff… - Frontiers in …, 2021 - frontiersin.org
Atopic dermatitis (AD) is a multifaceted, chronic relapsing inflammatory skin disease that
affects people of all ages. It is characterized by chronic eczema, constant pruritus, and …