Cell-based and stem-cell-based treatments for spinal cord injury: evidence from clinical trials

CM Zipser, JJ Cragg, JD Guest, MG Fehlings… - The Lancet …, 2022 - thelancet.com
Spinal cord injury is a severely disabling neurological condition leading to impaired mobility,
pain, and autonomic dysfunction. Most often, a single traumatic event, such as a traffic or …

Peripheral white blood cell responses as emerging biomarkers for patient stratification and prognosis in acute spinal cord injury

T Jogia, MA Kopp, JM Schwab… - Current Opinion in …, 2021 - journals.lww.com
Peripheral white blood cell responses as emerging biomarkers... : Current Opinion in
Neurology Peripheral white blood cell responses as emerging biomarkers for patient …

Pathophysiology, classification and comorbidities after traumatic spinal cord injury

J Guest, N Datta, G Jimsheleishvili… - Journal of personalized …, 2022 - mdpi.com
The spinal cord is a conduit within the central nervous system (CNS) that provides ongoing
communication between the brain and the rest of the body, conveying complex sensory and …

Segmental motor recovery after cervical spinal cord injury relates to density and integrity of corticospinal tract projections

G Balbinot, G Li, S Kalsi-Ryan, R Abel, D Maier… - Nature …, 2023 - nature.com
Cervical spinal cord injury (SCI) causes extensive impairments for individuals which may
include dextrous hand function. Although prior work has focused on the recovery at the …

Association of CSF and serum neurofilament light and glial fibrillary acidic protein, injury severity, and outcome in spinal cord injury

S Stukas, J Cooper, J Gill, N Fallah, MA Skinnider… - Neurology, 2023 - AAN Enterprises
Background and Objectives Traumatic spinal cord injury (SCI) is highly heterogeneous, and
tools to better delineate pathophysiology and recovery are needed. Our objective was to …

International surveillance study in acute spinal cord injury confirms viability of multinational clinical trials

L Bourguignon, B Tong, F Geisler, M Schubert… - BMC medicine, 2022 - Springer
Background The epidemiological international landscape of traumatic spinal cord injury
(SCI) has evolved over the last decades along with given inherent differences in acute care …

Management of acute spinal cord injury: Where have we been? Where are we now? Where are we going?

MG Fehlings, K Pedro, N Hejrati - Journal of Neurotrauma, 2022 - liebertpub.com
The strides that have been achieved in the realm of spinal cord injury (SCI) management are
remarkable. It is likely that 90% of what has been recognized to date about SCI …

Spontaneous motor recovery after cervical spinal cord injury: issues for nerve transfer surgery decision making

J Dengler, JD Steeves, A Curt, M Mehra, CB Novak… - Spinal cord, 2022 - nature.com
Study design Retrospective cohort study. Objectives To quantify spontaneous upper
extremity motor recovery between 6 and 12 months after spinal cord injury (SCI) to help …

Impact of surgical timing on motor level lowering in motor complete traumatic spinal cord injury patients

PV Ter Wengel, EEA de Gendt, E Martin… - Journal of …, 2022 - liebertpub.com
Patients with complete traumatic spinal cord injury (tSCI) have a low potential to recover
ambulation. Motor level recovery, adjacent to the level of injury, could influence functional …

Association of upper-limb neurological recovery with functional outcomes in high cervical spinal cord injury

S Javeed, JK Greenberg, JK Zhang, B Plog… - … of Neurosurgery: Spine, 2023 - thejns.org
OBJECTIVE High cervical spinal cord injury (SCI) results in complete loss of upper-limb
function, resulting in debilitating tetraplegia and permanent disability. Spontaneous motor …