Abstract Background In October 2013, the Declaration of Helsinki was revised a seventh
time in its 50 year history. While it is the most widely accepted set of ethical principles for the …

We treated 119 consecutive patients with lymphedema with complex lymphedema therapy
(CLT). Lymphedema reductions after CLT averaged 62.6% in the 56 patients with one …

Background Most patients with chronic obstructive pulmonary disease (COPD) receive
inhaled long-acting bronchodilators and inhaled corticosteroids. Conventional meta …

When is clinical research in developing countries exploitation? Exploitation is a concept in
ordinary moral thought that has not often been analyzed outside the Marxist tradition. Yet it is …

OBJECTIVE: This article examines the role of placebos in evaluating the efficacy of
psychiatric drugs. Also addressed are the identification of placebo effects on drugs, the …

Background The relatively recent introduction of biological agents to treat psoriasis presents
clinicians with the need to objectively compare and contrast these agents to allow more …

Placebo-controlled trials are held by many, including regulators at agencies like the United
States Food and Drug Administration (FDA), to be the gold standard in the assessment of …

The field of psychiatry has an opportunity to construct a more refined, perhaps more
enduring understanding of the ethical basis of mental illness research. The aim of this paper …

Researchers have a number of different options for their choice of control or comparison
intervention in randomized trials. We surveyed the methodological literature looking for …

A rich academic literature exists about issues of informed consent in medical care, and, to a
lesser extent, about a variety of issues posed by human experimentation. Most …