There is new and increasing evidence from in vitro, in vivo and clinical studies implicating
the pivotal role of iron and associated metabolic pathways in the initiation, progression and …

The pathologic triangle formed by chronic heart failure (HF), chronic kidney disease (CKD),
and anemia carries high morbidity and mortality rates and decreases quality of life. Anemia …

The need for preparing new strategies for the design of emergency drug therapies against
COVID-19 and similar diseases in the future is rather urgent, considering the high rate of …

The historical insights and background of the discovery, development and clinical use of
deferiprone (L1) and the maltol–iron complex, which were discovered over 40 years ago …

Introduction Hypoxia-inducible factor (HIF) mediates multiple intracellular processes that
drive cellular metabolism and induce proliferation. Dysregulated HIF expression is …

The hypoxia-inducible factors are α, β-heterodimeric transcription factors that mediate the
chronic response to hypoxia in humans and other animals. Protein hydroxylases belonging …

The kidneys are the most vulnerable organs to severe ischemic insult that results in cellular
hypoxia under pathophysiological conditions. Large amounts of oxygen are consumed by …

Pharmacological activation of hypoxia-inducible factor 1 (HIF-1), a hypoxia-responsive
transcription factor, has attracted increasing attention due to its efficacy not only in renal …

Patients with chronic kidney disease (CKD) often experience mild cognitive impairment and
other neurocognitive disorders. Studies have shown that erythropoietin (EPO) and its …

Background. Ischemia and reperfusion injury (IRI) determines primary allograft function after
liver transplantation (LT). Primary graft dysfunction (PGD) is associated with increased …