Abstract Alzheimer's disease (AD), as the fourth leading cause of death among the elderly
worldwide, has brought enormous challenge to the society. Due to its extremely complex …

Introducing novel strategies, concepts, and technologies that speed up drug discovery and
the drug development cycle is of great importance both in the highly competitive …

In an effort to develop new therapeutic agents to treat Alzheimer's disease, a series of
donepezil-based analogs were designed, synthesized using an environmentally friendly …

New compounds containing thiazole and pyridinium moieties were designed and
synthesized. The potency of the synthesized compounds as selective inhibitors of …

Syntheses of highly functionalized 4-alkylated 1, 4-dihydropyridines (1, 4-DHPs) from cyclic
ethers and enaminones via iron (II)-mediated oxidative free radical cascade C (sp3)–H bond …

Alzheimer's disease (AD) is characterized by progressive cognitive impairment and mental
behavior. The combination inhibition of two essential AD targets, acetylcholinesterase …

Multi-target-directed ligands (MTDLs) centered on β-secretase 1 (BACE-1) inhibition are
emerging as innovative therapeutics in addressing the complexity of neurodegenerative …

A small library of molecules combining indolizine and N-alkyl pyridinium was synthesized
and evaluated in a multi-target-directed-ligand strategy for Alzheimer's disease (AD) …

Dihydro-5, 6-dimethoxy-2-[4-(4-alkyl-4-methylpiperazinium-1-yl) benzylidine]-1H-inden-1-
one halide salt derivatives as a novel donepezil hybrid analogs with the property of …

Acetylcholinesterase (AChE) is currently one of the potent targets for the treatment of
Alzheimer's disease (AD). The discovery of promising new AChE inhibitors using a …