As FDA-approved small RNA drugs start to enter clinical medicine, ongoing studies for the
microRNA (miRNA) class of small RNAs expand its preclinical and clinical research …

Huntington's disease is caused by an abnormally expanded CAG repeat expansion in the
HTT gene, which confers a predominant toxic gain of function in the mutant huntingtin …

Huntington disease is devastating to patients and their families—with autosomal dominant
inheritance, onset typically in the prime of adult life, progressive course, and a combination …

Background TRACK-HD is a prospective observational biomarker study in premanifest and
early Huntington's disease (HD). In this report we define a battery of potential outcome …

Huntington disease (HD) can be seen as a model neurodegenerative disorder, in that it is
caused by a single genetic mutation and is amenable to predictive genetic testing, with …

Huntington's disease (HD) is a neurodegenerative disorder that manifests with movement
dysfunction. The expression of mutant Huntingtin (mHTT) disrupts the functions of brain …

This fourth edition of Huntington's Disease presents a comprehensive summary of the
current knowledge of this disease, including the major scientific and clinical advances that …

Huntington's disease (HD) is an autosomal neurodegenerative disorder, characterized by
severe behavioral, cognitive, and motor deficits. Since the discovery of the huntingtin gene …

Introduction Executive dysfunctions constitute a significant public health problem: their high
impact on everyday life makes it a priority to identify early strategies for evaluating and …

Molecular diagnostics provide a powerful method to detect and diagnose various
neurological diseases such as Alzheimer's and Parkinson's disease. The confirmation of …