[HTML][HTML] The potential for microRNA therapeutics and clinical research
J Hanna, GS Hossain, J Kocerha - Frontiers in genetics, 2019 - frontiersin.org
As FDA-approved small RNA drugs start to enter clinical medicine, ongoing studies for the
microRNA (miRNA) class of small RNAs expand its preclinical and clinical research …
microRNA (miRNA) class of small RNAs expand its preclinical and clinical research …
[HTML][HTML] Huntingtin lowering strategies for disease modification in Huntington's disease
SJ Tabrizi, R Ghosh, BR Leavitt - Neuron, 2019 - cell.com
Huntington's disease is caused by an abnormally expanded CAG repeat expansion in the
HTT gene, which confers a predominant toxic gain of function in the mutant huntingtin …
HTT gene, which confers a predominant toxic gain of function in the mutant huntingtin …
Huntington disease
Huntington disease is devastating to patients and their families—with autosomal dominant
inheritance, onset typically in the prime of adult life, progressive course, and a combination …
inheritance, onset typically in the prime of adult life, progressive course, and a combination …
Potential endpoints for clinical trials in premanifest and early Huntington's disease in the TRACK-HD study: analysis of 24 month observational data
Background TRACK-HD is a prospective observational biomarker study in premanifest and
early Huntington's disease (HD). In this report we define a battery of potential outcome …
early Huntington's disease (HD). In this report we define a battery of potential outcome …
Huntington disease: natural history, biomarkers and prospects for therapeutics
CA Ross, EH Aylward, EJ Wild, DR Langbehn… - Nature Reviews …, 2014 - nature.com
Huntington disease (HD) can be seen as a model neurodegenerative disorder, in that it is
caused by a single genetic mutation and is amenable to predictive genetic testing, with …
caused by a single genetic mutation and is amenable to predictive genetic testing, with …
[HTML][HTML] Galectin-3 is required for the microglia-mediated brain inflammation in a model of Huntington's disease
Huntington's disease (HD) is a neurodegenerative disorder that manifests with movement
dysfunction. The expression of mutant Huntingtin (mHTT) disrupts the functions of brain …
dysfunction. The expression of mutant Huntingtin (mHTT) disrupts the functions of brain …
[HTML][HTML] Characterization of neurophysiological and behavioral changes, MRI brain volumetry and 1H MRS in zQ175 knock-in mouse model of Huntington's disease
T Heikkinen, K Lehtimäki, N Vartiainen, J Puoliväli… - PloS one, 2012 - journals.plos.org
Huntington's disease (HD) is an autosomal neurodegenerative disorder, characterized by
severe behavioral, cognitive, and motor deficits. Since the discovery of the huntingtin gene …
severe behavioral, cognitive, and motor deficits. Since the discovery of the huntingtin gene …
[HTML][HTML] Available virtual reality-based tools for executive functions: a systematic review
Introduction Executive dysfunctions constitute a significant public health problem: their high
impact on everyday life makes it a priority to identify early strategies for evaluating and …
impact on everyday life makes it a priority to identify early strategies for evaluating and …
[HTML][HTML] Molecular diagnostics of neurodegenerative disorders
M Agrawal, A Biswas - Frontiers in molecular biosciences, 2015 - frontiersin.org
Molecular diagnostics provide a powerful method to detect and diagnose various
neurological diseases such as Alzheimer's and Parkinson's disease. The confirmation of …
neurological diseases such as Alzheimer's and Parkinson's disease. The confirmation of …