Enormous progress has been made in the last half-century in the management of diseases
closely integrated with excess body weight, such as hypertension, adult-onset diabetes and …

ABSTRACT A recent Perspective article described the “carbohydrate-insulin model (CIM)” of
obesity, asserting that it “better reflects knowledge on the biology of weight control” as …

Observational findings achieved during the past two decades suggest that the intestinal
microbiota may contribute to the metabolic health of the human host and, when aberrant, to …

Genome-wide association studies (GWAS) involve testing genetic variants across the
genomes of many individuals to identify genotype–phenotype associations. GWAS have …

The exponential growth of pollutant discharges into the environment due to increasing
industrial and agricultural activities is a rising threat for human health and a biggest concern …

Late eating has been linked to obesity risk. It is unclear whether this is caused by changes in
hunger and appetite, energy expenditure, or both, and whether molecular pathways in …

Obesity is a global epidemic characterized by energy disequilibrium, metabolic disorder, fat
mass development, and chronic low-grade inflammation, which significantly affects the …

Obesity is prevalent in the US population and contributes significantly to morbidity and
mortality. Treatments include behavioral therapy, pharmacotherapy, and bariatric surgery …

Diverse evidence suggests that the gut microbiota is involved in the development of obesity
and associated comorbidities. It has been reported that the composition of the gut microbiota …

The recent epidemics of metabolic diseases, obesity, type 2 diabetes (T2D), liver lipid
disorders and metabolic syndrome have largely been attributed to genetic background and …