Interest in the relationships between the pharmacokinetics (PK) and pharmacodynamics
(PD) of antimicrobial agents has increased over recent years. Since the appearance 2 years …

Continuous renal replacement therapy (CRRT), particularly continuous venovenous
haemofiltration (CVVH) and continuous venovenous haemodiafiltration (CVVHDF), are …

Piperacillin-tazobactam (PTZ) is one of the most common antibiotics administered to
hospitalized patients. Its broad activity against gram-negative, gram-positive, and anaerobic …

Piperacillin/tazobactam is a β-lactam/β-lactamase inhibitor combination with a broad
spectrum of antibacterial activity encompassing most Gram-positive and Gram-negative …

Objectives Appropriate antibiotic exposure at the site of infection is important for clinically
effective therapy. This study compared the epithelial lining fluid (ELF) penetration of …

Piperacillin–tazobactam is a β-lactam/β-lactamase inhibitor combination with a broad
spectrum of antibacterial activity that includes Gram-positive and-negative aerobic and …

The aim of this study was to determine whether Galleria mellonella larvae can be used (i) as
an in vivo infection model for Pseudomonas aeruginosa and (ii) for evaluating the …

Although early and appropriate antibiotic therapy remains the most important intervention for
successful treatment of septic shock, data guiding optimization of beta-lactam prescription in …

Objectives This study describes a comprehensive programme designed to develop
pharmacokinetic–pharmacodynamic (PK–PD) breakpoints for numerous antimicrobial …

A common cause of acute kidney injury (AKI) is sepsis, which makes appropriate dosing of
antibiotics in these patients essential. Drug dosing in critically ill patients with AKI, however …