The primary objectives of this analysis were to determine which pharmacokinetic model
most accurately describes the elimination pathways for piperacillin in the presence of …

Over the last decades, the interest in the relationships between the pharmacokinetics (PK)
and pharmacodynamics (PD) of antimicrobial agents has increased and, therefore, the use …

We assessed infections caused by extended-spectrum-β-lactamase-producing Escherichia
coli or Klebsiella spp. treated with piperacillin-tazobactam to determine if the susceptibility …

Rapid emergence of resistance against antibacterial s emphasizes the need for the
development of novel and/or more potent antibacterials. Tigecycline is the first …

The OPTAMA Program is intended to examine typical antimicrobial regimens used in the
treatment of common nosocomial pathogens and the likelihood of these regimens attaining …

The pharmacokinetics of piperacillin-tazobactam were investigated in eight anuric intensive
care patients treated by continuous venovenous hemodialysis (CVVHD). The elimination …

The study objective was to evaluate the population pharmacokinetics and
pharmacodynamics of piperacillin and tazobactam administered by prolonged infusion in …

Breakpoints are the values used by clinical microbiology laboratories to interpret the results
of antimicrobial susceptibility testing (AST) and classify isolates as susceptible or resistant …

TO THE EDITOR—In January 2023, the Clinical and Laboratory Standards Institute (CLSI)
revised the piperacillintazobactam (PTZ) interpretive criteria against Pseudomonas …

Background: Prolonging the infusion of a β-lactam antibiotic enhances the time in which
unbound drug concentrations remain above the minimum inhibitory concentration (fT> MIC) …