Alzheimer's disease is a rather complex neurodegenerative disease, which is attributed to a
combination of multiple factors. Among the many pathological pathways, synaptic …

We describe a recently recognized disease entity, limbic-predominant age-related TDP-43
encephalopathy (LATE). LATE neuropathological change (LATE-NC) is defined by a …

Dominantly inherited Alzheimer's disease (DIAD) causes predictable biological changes
decades before the onset of clinical symptoms, enabling testing of interventions in the …

As we age, we experience changes in our nighttime sleep and daytime wakefulness.
Individuals afflicted with Alzheimer's disease (AD) can develop sleep problems even before …

Alzheimer's disease (AD) is a progressive neurodegenerative disorder that is characterized
by cognitive decline and the presence of two core pathologies, amyloid β plaques and …

Cancer and Alzheimer's disease (AD) are characterized by (i) opposing biological
mechanisms,(ii) an inverse correlation between their incidences, and (iii) oxidative stress …

Alzheimer's disease (AD) is a devastating neurodegenerative disorder without a cure. Most
AD cases are sporadic where age represents the greatest risk factor. Lack of understanding …

Alzheimer's disease (AD) is a progressive neurodegenerative disorder and the most
common cause for dementia. There are many hypotheses about AD, including abnormal …

The pathogenesis of Alzheimer's disease involves β amyloid (Aβ) accumulation known to
induce synaptic dysfunction and neurodegeneration. The brain's vulnerability to oxidative …

Dysfunction of cell bioenergetics is a common feature of neurodegenerative diseases, the
most common of which is Alzheimer's disease (AD). Disrupted energy utilization implicates …