Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disorder affecting primarily the
motor system, but in which extra‐motor manifestations are increasingly recognized. The loss …

Individuals who are diagnosed with amyotrophic lateral sclerosis (ALS) today face the same
historically intransigent problem that has existed since the initial description of the disease in …

Neuroaxonal damage is the pathological substrate of permanent disability in various
neurological disorders. Reliable quantification and longitudinal follow-up of such damage …

Neuronal injury is a universal event that occurs in disease processes that affect both the
central and peripheral nervous systems. A blood biomarker linked to neuronal injury would …

Cerebrospinal fluid analyses and neuroimaging can identify the underlying pathophysiology
at the earliest stage of some neurodegenerative disorders, but do not have the scalability …

Objective To evaluate plasma phosphorylated neurofilament heavy chain (pNF‐H) as a
biomarker in spinal muscular atrophy (SMA). Methods Levels of pNF‐H were measured …

Objective To determine the diagnostic and prognostic performance of serum neurofilament
light chain (NFL) in amyotrophic lateral sclerosis (ALS). Methods This single-centre …

Objective To identify preferred neurofilament assays and clinically validate serum
neurofilament light (NfL) and phosphorylated neurofilament heavy (pNfH) as prognostic and …

Introduction We tested how tube types (ethylenediaminetetraacetic acid [EDTA], serum,
lithium heparin [LiHep], and citrate) and freeze–thaw cycles affect levels of blood biomarkers …

Motor neuron diseases (MNDs) are etiologically and biologically heterogeneous diseases.
The pathobiology of motor neuron degeneration is still largely unknown, and no effective …