Splenomegaly in children and adolescents

M Suttorp, CF Classen - Frontiers in pediatrics, 2021 - frontiersin.org
In contrast to other lymphoid tissues making up the immune system, the spleen as its biggest
organ is directly linked into the blood circulation. Beside its main task to filter out …

Management of children and adolescents with chronic myeloid leukemia in blast phase: International pediatric CML expert panel recommendations

S Sembill, M Ampatzidou, S Chaudhury, M Dworzak… - Leukemia, 2023 - nature.com
Abstract Treatment of chronic myeloid leukemia has improved significantly with the
introduction of tyrosine kinase inhibitors (TKIs), and treatment guidelines based on …

Minimal residual disease in BCR:: ABL1-positive acute lymphoblastic leukemia: different significance in typical ALL and in CML-like disease

J Zuna, L Hovorkova, J Krotka, A Koehrmann… - Leukemia, 2022 - nature.com
Recently, we defined “CML-like” subtype of BCR:: ABL1-positive acute lymphoblastic
leukemia (ALL), resembling lymphoid blast crisis of chronic myeloid leukemia (CML). Here …

Discontinuation of imatinib in children with chronic myeloid leukemia: A study from the international registry of childhood CML

F Millot, M Suttorp, S Ragot, G Leverger, JH Dalle… - Cancers, 2021 - mdpi.com
Simple Summary About 50% of adults with chronic myeloid leukemia (CML) in sustained
deep molecular response (DMR) to tyrosine kinase inhibitors (TKI) could discontinue the …

Integrated genomic analysis identifies ankrd36 gene as a novel and common biomarker of disease progression in chronic myeloid leukemia

Z Iqbal, M Absar, T Akhtar, A Aleem, A Jameel, S Basit… - Biology, 2021 - mdpi.com
Simple Summary Chronic myeloid leukemia is a type of blood cancer that is regarded as a
success story in determining the exact biological origin, pathogenesis and development of a …

Patterns of bone marrow confirmed malignant and non-malignant hematological disorders in patients with abnormal hematological parameters in Northeast Ethiopia

H Ebrahim, T Fisha, H Debash… - Journal of Blood …, 2022 - Taylor & Francis
Background Hematological disorders are heterogeneous conditions ranging from malignant
to non-malignant disorders. Hematological malignancies comprise a collection of …

Continuous therapy response references for BCR::ABL1 monitoring in pediatric chronic myeloid leukemia

C Volz, T Zerjatke, A Gottschalk, S Semper… - Scientific Reports, 2023 - nature.com
Response to tyrosine kinase inhibitor (TKI) therapy in patients with chronic myeloid leukemia
(CML) is monitored by quantification of BCR:: ABL1 transcript levels. Milestones for …

Health-related quality of life in children with chronic myeloid leukemia in the chronic phase

F Zheng, X Dou, L Zhang, J Jin, Y Zhang, B Liu… - Journal of cancer …, 2022 - Springer
Purpose This study aimed to explore the health-related quality of life (HRQoL) and
associated variables in children with chronic myeloid leukemia in the chronic phase (CML …

The cytogenetic landscape of pediatric chronic myeloid leukemia diagnosed in chronic phase

A Karow, G Göhring, S Sembill, F Lutterloh, F Neuhaus… - Cancers, 2022 - mdpi.com
Simple Summary Philadelphia chromosome-positive chronic myeloid leukemia (CML) is
characterized by the translocation of the chromosomes 9 and 22. Additional non …

Preservation of fertility in female patients with hematologic diseases

MB Antunes, SP Cardeal, M Magalhães… - Blood Reviews, 2023 - Elsevier
Recent developments of assisted reproduction techniques turned possible to avoid the
infertility consequences of oncologic treatments, but fertility preservation (FP) has been …