Nucleic acid extraction (NAE) plays a vital role in molecular biology as the primary step for
many downstream applications. Many modifications have been introduced to the original …

Introduction: The availability of simple, tolerable, therapies for hepatitis C virus (HCV)
infection with responses> 95% is one of the greatest medical advances in decades, offering …

Background Slow and cumbersome laboratory diagnostics for Mycobacterium tuberculosis
complex (MTBC) risk delayed treatment and poor patient outcomes. Whole-genome …

Tuberculosis (TB) caused by Mycobacterium tuberculosis (MTB) is the deadliest infectious
disease and the associated global threat has worsened with the emergence of drug …

Rationale: High-dose isoniazid is recommended in short-course regimens for multidrug-
resistant tuberculosis (TB). The optimal dose of isoniazid and its individual contribution to …

Tuberculosis is the infectious disease that causes the most deaths each year in the world.
Around 25% of the population is estimated to be infected with, Mycobacterium tuberculosis …

Background There is an urgent demand for rapid and accurate drug-susceptibility testing for
the detection of multidrug-resistant tuberculosis. The GenoType MTBDR plus assay is a …

Background Mycoplasma genitalium (MG) causes symptomatic urethritis in men, and can
infect alone or together with other sexually transmitted infection (STI) agents. Methods The …

Diagnosing pulmonary sarcoidosis raises challenges due to both the absence of a specific
diagnostic criterion and the varied presentations capable of mimicking many other …

Background An increasing number of countries with low incidence of tuberculosis have pre-
entry screening programmes for migrants. We present the first estimates of the prevalence of …