Chemotherapeutics occupy a pivotal role in the medication of different types of cancers, but
the prevalence and mortality rates of cancer remain high. The drug resistance and low …

Fluorine-containing small molecules have occupied an especial position in drug discovery
research. The successful clinical use of fluorinated corticosteroids in the 1950s and …

Alterations of discoidin domain receptor1 (DDR1) may lead to increased production of
inflammatory cytokines, making DDR1 an attractive target for inflammatory bowel disease …

Fibroblast growth factor receptors (FGFR) are an essential player in oncogenesis and tumor
progression. LY2874455 was identified as a pan-FGFR inhibitor and has gone through …

26 derivatives of myricetin containing pyridazinone were designed and synthesized from the
natural product myricitrin, which were structurally characterized by nuclear magnetic …

To search for potent CDK4/6 covalent inhibitors, total 14 compounds have been designed
and synthesized by connecting different Michael-acceptor to the piperazine moiety of …

Pyridazinones are important nitrogen‐rich heterocyclic core that has been driving the
substantial medicinal interest due to their wide range of biological activities. This privileged …

Covalent inhibitors have been used to treat several diseases for over a century. However,
strategic approaches for the rational design of covalent drugs have taken a definitive shape …

Developing highly potent covalent inhibitors of Fibroblast growth factor receptors 1 (FGFR1)
has always been a challenging task. In the current study, various computational techniques …

Kinase inhibitors are crucial in cancer treatment, but drug resistance and side effects hinder
the development of effective drugs. To address these challenges, it is essential to analyze …