α-Granules are essential to normal platelet activity. These unusual secretory granules derive
their cargo from both regulated secretory and endocytotic pathways in megakaryocytes …

Rheumatoid arthritis (RA) is associated with excess morbidity and mortality from myocardial
infarction and allied disorders. A large body of evidence supports the involvement of …

Habitual sleep duration has been associated with cardiometabolic disease, via several
mechanistic pathways, but few have been thoroughly explored. One hypothesis is that short …

BACKGROUND: MicroRNAs are being used in the oncology field to characterize tumors and
predict the survival of cancer patients. Here, we explored the potential of microRNAs as …

Abstract Alterations of Endothelial cells (ECs) play a critical role in different pathogenesis of
many serious human diseases, and dysfunction of the vascular endothelium is an indicator …

Extracellular matrix (ECM) within the vascular network provides both a structural and
regulatory role. The ECM is a dynamic composite of multiple proteins that form structures …

Over the last decade, it has become clear that the accumulation of misfolded proteins
contributes to a number of neurodegenerative, immune, and endocrine pathologies, as well …

Abstract Leukotrienes (LTs) derived from 5-lipoxygenase (5-LO) activity are most widely
known for their actions during acute inflammation and asthma. 5-LO/LT pathway …

Osteoarthritis (OA) is an age-related degenerative disease comprising the main reason of
handicap in the Western world. Interestingly, to date, there are neither available biomarkers …

Mexico City children are chronically exposed to significant concentrations of air pollutants
and exhibit chronic respiratory-tract inflammation. Epidemiological, controlled human …