Im Rahmen einer allogenen Blutstammzelltransplantation kommt es häufig zu
immunhämatologischen Phänomenen, die im Rahmen der Diagnostik und der supportiven …

Im Rahmen einer allogenen Blutstammzelltransplantation kommt es häufig zu
immunhämatologischen Phänomenen, die im Rahmen der Diagnostik und der supportiven …

Platelet transfusion refractoriness (PTR) can be defined as the less increment of platelet
count than expected after platelets transfusion, which is a challenging and expensive …

Infantile (fetal and neonatal) megakaryocytes have a distinct phenotype consisting of
hyperproliferation, limited morphogenesis, and low platelet production capacity. These …

PTR results from immune (anti-HLA or anti-HPA antibodies) or, more commonly, non-
immune mechanisms (bleeding, sepsis, fever, or splenomegaly). Bleeding in these patients …

See article on page 2307–2316, in this issue

HLA antibodies are the most common cause of immune refractoriness in thrombocytopenic
patients requiring repeated platelet transfusions. Management of HLA platelet refractoriness …