In this work, we review clinical features and genetic diagnosis of diseases caused by
mutations in the gene encoding valosin-containing protein (VCP/p97), the functionally …

Frontotemporal dementia comprises a group of clinical syndromes that are characterised by
progressive changes in behaviour, executive function, or language. The term frontotemporal …

Objective We tested the hypothesis that plasma neurofilament light chain (NfL) identifies
asymptomatic carriers of familial frontotemporal lobar degeneration (FTLD)–causing …

At present, no research criteria exist for the diagnosis of prodromal behavioural variant
frontotemporal dementia (bvFTD), though early detection is of high research importance …

Heterozygous, loss-of-function mutations in the granulin gene (GRN) encoding progranulin
(PGRN) are a common cause of frontotemporal dementia (FTD). Homozygous GRN …

Unlike familial Alzheimer's disease, we have been unable to accurately predict symptom
onset in presymptomatic familial frontotemporal dementia (f-FTD) mutation carriers, which is …

There is a longstanding ambiguity regarding the clinical diagnosis of dementia syndromes
predominantly targeting executive functions versus behaviour and personality. This is due to …

Importance Physical activity is associated with cognitive health, even in autosomal dominant
forms of dementia. Higher physical activity is associated with slowed cognitive and …

Techniques for clinical genetic testing in dementia disorders have advanced rapidly but
remain to be more widely implemented in practice. A positive genetic test offers a precise …

Objective Despite the strong genetic component of frontotemporal dementia (FTD), a
substantial proportion of patients remain genetically unresolved. We performed an in-depth …