Asymmetric organocatalysis: an enabling technology for medicinal chemistry

B Han, XH He, YQ Liu, G He, C Peng… - Chemical Society Reviews, 2021 - pubs.rsc.org
The efficacy and synthetic versatility of asymmetric organocatalysis have contributed
enormously to the field of organic synthesis since the early 2000s. As asymmetric …

[HTML][HTML] Colon cancer and colorectal cancer: Prevention and treatment by potential natural products

MR Islam, S Akash, MM Rahman, FT Nowrin… - Chemico-biological …, 2022 - Elsevier
Colon cancer affects both men and women and is the world's second most significant cause
of cancer-related mortality. Colon cancer death rates have risen worldwide due to the …

An overview of spirooxindole as a promising scaffold for novel drug discovery

LM Zhou, RY Qu, GF Yang - Expert Opinion on Drug Discovery, 2020 - Taylor & Francis
Introduction: Spirooxindole, a unique and versatile scaffold, has been widely studied in
some fields such as pharmaceutical chemistry and synthetic chemistry. Especially in the …

Recent developments in natural and synthetic polymeric drug delivery systems used for the treatment of osteoarthritis

M Rahimi, G Charmi, K Matyjaszewski, X Banquy… - Acta biomaterialia, 2021 - Elsevier
Osteoarthritis (OA), is a common musculoskeletal disorder that will progressively increase in
older populations and is expected to be the most dominant cause of disability in the world …

[HTML][HTML] Natural products for treating colorectal cancer: A mechanistic review

X Huang, Z Yang, Q Xie, Z Zhang, H Zhang… - Biomedicine & …, 2019 - Elsevier
Colorectal cancer (CRC) is one of the most common types of cancers in humans and is
closely linked to the global cancer-related mortalities worldwide. Molecular pathological …

Marine anticancer agents: An overview with a particular focus on their chemical classes

M Barreca, V Spanò, A Montalbano, M Cueto… - Marine drugs, 2020 - mdpi.com
The marine environment is a rich source of biologically active molecules for the treatment of
human diseases, especially cancer. The adaptation to unique environmental conditions led …

Expatiating the pharmacological and nanotechnological aspects of the alkaloidal drug berberine: current and future trends

T Behl, S Singh, N Sharma, I Zahoor, A Albarrati… - Molecules, 2022 - mdpi.com
Traditionally, herbal compounds have been the focus of scientific interest for the last several
centuries, and continuous research into their medicinal potential is underway. Berberine …

Coumarins from carcinogenic phenol: synthesis, characterization, in silico, biosafety, anticancer, antioxidant, and anti-inflammatory assessments

YF Mustafa - Chemical Papers, 2024 - Springer
Since 1947, a sterically hindered phenol named 3-(tert-butyl)-4-methoxyphenol, abbreviated
here as 3-tBMP, has been widely used as a powerful preservative antioxidant for food …

Naturally derived indole alkaloids targeting regulated cell death (RCD) for cancer therapy: from molecular mechanisms to potential therapeutic targets

R Qin, FM You, Q Zhao, X Xie, C Peng, G Zhan… - Journal of hematology & …, 2022 - Springer
Regulated cell death (RCD) is a critical and active process that is controlled by specific
signal transduction pathways and can be regulated by genetic signals or drug interventions …

[PDF][PDF] Phytochemical, antioxidant and antitumor studies of coumarins extracted from Granny Smith apple seeds by different methods

RR Khalil, YF Mustafa - Systematic Reviews in Pharmacy, 2020 - researchgate.net
The management of many human diseases linked to oxidative stress requires extensive
research to explore novel agents with a potential antioxidant activity. In this study, the seeds …